BACKGROUND: The optimal indocyanine green (ICG) administration protocol for fluorescence cholangiography during laparoscopic cholecystectomy (LC) has yet to be determined. METHODS: A prospective study including 20 cases of ICG fluorescence-navigated LC was conducted. Accordingly, the first 10 patients were administered 2.5 mg of ICG on the day of surgery after intubation (surgery-day group), while the remaining 10 consecutive patients were administered 0.25 mg/kg of ICG on the evening before surgery (one-day-before group). Fluorescence intensity (FI) of each tissue and FI ratios were then compared between both groups. RESULTS: The median interval between observation and ICG administration was 27 minutes and 16 hours 24 minutes in the surgery-day and one-day-before group, respectively. Although FI values for the common bile duct (CBD), liver, and hepatoduodenal ligament (HDL) were significantly lower in the one-day-before group than in the surgery-day group, CBD- , 0.6-1.2 vs 2.5, 0.9 = -4.8; P < .001), and CBD-HDL contrast (1.7, 1.4-2.4 vs 2.3, 1.5-13.3; P = .038) were significantly higher in the one-day-before group than in the surgery-day group. CONCLUSION: ICG administration a day before LC may offer better CBD background contrast compared to administration just prior to surgery.
BACKGROUND: The optimal indocyanine green (ICG) administration protocol for fluorescence cholangiography during laparoscopic cholecystectomy (LC) has yet to be determined. METHODS: A prospective study including 20 cases of ICG fluorescence-navigated LC was conducted. Accordingly, the first 10 patients were administered 2.5 mg of ICG on the day of surgery after intubation (surgery-day group), while the remaining 10 consecutive patients were administered 0.25 mg/kg of ICG on the evening before surgery (one-day-before group). Fluorescence intensity (FI) of each tissue and FI ratios were then compared between both groups. RESULTS: The median interval between observation and ICG administration was 27 minutes and 16 hours 24 minutes in the surgery-day and one-day-before group, respectively. Although FI values for the common bile duct (CBD), liver, and hepatoduodenal ligament (HDL) were significantly lower in the one-day-before group than in the surgery-day group, CBD- , 0.6-1.2 vs 2.5, 0.9 = -4.8; P < .001), and CBD-HDL contrast (1.7, 1.4-2.4 vs 2.3, 1.5-13.3; P = .038) were significantly higher in the one-day-before group than in the surgery-day group. CONCLUSION:ICG administration a day before LC may offer better CBD background contrast compared to administration just prior to surgery.
Authors: Lidia Castagneto-Gissey; Maria Francesca Russo; Alessandra Iodice; James Casella-Mariolo; Angelo Serao; Andrea Picchetto; Giancarlo D'Ambrosio; Irene Urciuoli; Alessandro De Luca; Bruno Salvati; Giovanni Casella Journal: J Clin Med Date: 2022-06-17 Impact factor: 4.964
Authors: Dragos Serban; Dumitru Cristinel Badiu; Dragos Davitoiu; Ciprian Tanasescu; Mihail Silviu Tudosie; Alexandru Dan Sabau; Ana Maria Dascalu; Corneliu Tudor; Simona Andreea Balasescu; Bogdan Socea; Daniel Ovidiu Costea; Anca Zgura; Andreea Cristina Costea; Laura Carina Tribus; Catalin Gabriel Smarandache Journal: Exp Ther Med Date: 2021-12-30 Impact factor: 2.447