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Literature DB >> 33087280

Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.

Abstract

With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polɩ), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polɩ remains unknown. Here, we provide a graphical review of the unique biochemical properties of polɩ and speculate about the cellular pathways in which enigmatic polɩ may participate.

Entities: Chemical Disease Gene Species

Keywords: Mutagenesis; Replicase; Replication fidelity; Translesion DNA synthesis; Y-family DNA polymerase

Mesh：

Substances：

Year: 2020 PMID： 33087280 PMCID： PMC7586464 DOI： 10.1016/j.dnarep.2020.102914

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

25 in total

2. Identification and Characterization of Thermostable Y-Family DNA Polymerases η, ι, κ and Rev1 From a Lower Eukaryote, Thermomyces lanuginosus.

Authors: Alexandra Vaisman; John P McDonald; Mallory R Smith; Sender L Aspelund; Thomas C Evans; Roger Woodgate
Journal: Front Mol Biosci Date: 2021-11-03

2 in total

Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.

Review 1. A plethora of lesion-replicating DNA polymerases.

2. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

Review 3. Translesion DNA polymerases in eukaryotes: what makes them tick?

4. 5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro.

Review 5. Polymerase iota - an odd sibling among Y family polymerases.

6. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota.

Review 7. Evolution of the two-step model for UV-mutagenesis.

8. Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota.

9. The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis.

10. Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese.

Review 1. Beyond the Lesion: Back to High Fidelity DNA Synthesis.

2. Identification and Characterization of Thermostable Y-Family DNA Polymerases η, ι, κ and Rev1 From a Lower Eukaryote, Thermomyces lanuginosus.