Literature DB >> 33085760

The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1.

Xuedan Guo1, Zhi Wang2, Qing Sun1, Chunhua Sun1, Hongxia Hua1, Qing Huang3.   

Abstract

Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC), and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis. In this study, we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC. The results showed that miR-1827 level was decreased in tumor tissues and cells and was correlated with tumor grade and lymph node (LN) metastasis. Overexpression of miR-1827 inhibited anchorage-independent growth and anoikis resistance in A549 cells. Bioinformatics and functional analysis identified that caveolin-1 (CAV-1) is directly targeted by miR-1827. Restoration of CAV-1 significantly attenuated miR-1827's effect on anoikis resistance in A549 cells. Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance, which might serve as a potential therapeutic target for metastatic NSCLC.
© The Author(s) 2020. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  A549 cell; NSCLC; anoikis resistance; caveolin-1; microRNA-1827

Mesh：

Substances：

Year:  2020        PMID： 33085760     DOI： 10.1093/abbs/gmaa102

Source DB:  PubMed          Journal:  Acta Biochim Biophys Sin (Shanghai)        ISSN： 1672-9145            Impact factor:   3.848


  5 in total

1.  MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia.

Authors:  Omran Davarinejad; Sajad Najafi; Hossein Zhaleh; Farzaneh Golmohammadi; Farnaz Radmehr; Mostafa Alikhani; Reza Heidari Moghadam; Yazdan Rahmati
Journal:  J Mol Neurosci       Date:  2021-11-22       Impact factor: 3.444

Review 2.  The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer.

Authors:  Han Yeoung Lee; Seung Wan Son; Sokviseth Moeng; Soo Young Choi; Jong Kook Park
Journal:  Int J Mol Sci       Date:  2021-01-10       Impact factor: 5.923

3.  Circ_0000808 promotes the development of non-small cell lung cancer by regulating glutamine metabolism via the miR-1827/SLC1A5 axis.

Authors:  Yong Cai; Zhiyi Dong; Jiying Wang
Journal:  World J Surg Oncol       Date:  2022-10-03       Impact factor: 3.253

Review 4.  Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies.

Authors:  Jing Wang; Zhijie Luo; Lizhu Lin; Xinbing Sui; Lili Yu; Cong Xu; Ruonan Zhang; Ziming Zhao; Qianru Zhu; Bo An; Qiao Wang; Bi Chen; Elaine Lai-Han Leung; Qibiao Wu
Journal:  Cancers (Basel)       Date:  2022-09-30       Impact factor: 6.575

5.  A Comprehensive Analysis of the Downregulation of miRNA-1827 and Its Prognostic Significance by Targeting SPTBN2 and BCL2L1 in Ovarian Cancer.

Authors:  Penghui Feng; Zhitong Ge; Zaixin Guo; Lin Lin; Qi Yu
Journal:  Front Mol Biosci       Date:  2021-06-11
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.