Jian Wang1, Zongyu Xie2, Xiandi Zhu1, Zhongfeng Niu3, Hongli Ji4, Linyang He4, Qiuxiang Hu4, Cui Zhang5. 1. Department of Radiology, Tongde Hospital of Zhejiang Province, Number 234, Road Gucui, Hangzhou, Zhejiang, China. 2. Department of Radiology, The First Affliated Hospital of Bengbu Medical College, Bengbu, Anhui, China. 3. Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, Zhejiang, China. 4. Jianpei Technology, Number 198, Road Qidi, Xiaoshan, Hangzhou, Zhejiang, China. 5. Department of Radiology, Tongde Hospital of Zhejiang Province, Number 234, Road Gucui, Hangzhou, Zhejiang, China. zc553217018@163.com.
Abstract
OBJECTIVE: To identify schwannomas from gastrointestinal stromal tumors (GISTs) by CT features using Logistic Regression (LR), Decision Trees (DT), Random Forest (RF), and Gradient Boosting Decision Tree (GBDT). METHODS: This study enrolled 49 patients with schwannomas and 139 with GISTs proven by pathology. CT features with P < 0.1 derived from univariate analysis were inputted to four models. Five machine learning (ML) versions, multivariate analysis, and radiologists' subjective diagnostic performance were compared to evaluate diagnosis performance of all the traditional and advanced methods. RESULTS: The CT features with P < 0.1 were as follows: (1) CT attenuation value of unenhancement phase (CTU), (2) portal venous enhancement (CTV), (3) degree of enhancement in the portal venous phase (DEPP), (4) CT attenuation value of portal venous phase minus arterial phase (CTV-CTA), (5) enhanced potentiality (EP), (6) location, (7) contour, (8) growth pattern, (9) necrosis, (10) surface ulceration, (11) enlarged lymph node (LN). LR (M1), RF, DT, and GBDT models contained all of the above 11 variables, while LR (M2) was developed using six most predictive variables derived from (M1). LR (M2) model with AUC of 0.967 in test dataset was thought to be optimal model in differentiating the two tumors. Location in gastric body, exophytic and mixed growth pattern, lack of necrosis and surface ulceration, enlarged lymph nodes, and larger EP were the most important CT features suggestive of schwannomas. CONCLUSION: LR (M2) provided the optimal diagnostic potency among other ML versions, multivariate analysis, and radiologists' performance on differentiation of schwannomas from GISTs.
OBJECTIVE: To identify schwannomas from gastrointestinal stromal tumors (GISTs) by CT features using Logistic Regression (LR), Decision Trees (DT), Random Forest (RF), and Gradient Boosting Decision Tree (GBDT). METHODS: This study enrolled 49 patients with schwannomas and 139 with GISTs proven by pathology. CT features with P < 0.1 derived from univariate analysis were inputted to four models. Five machine learning (ML) versions, multivariate analysis, and radiologists' subjective diagnostic performance were compared to evaluate diagnosis performance of all the traditional and advanced methods. RESULTS: The CT features with P < 0.1 were as follows: (1) CT attenuation value of unenhancement phase (CTU), (2) portal venous enhancement (CTV), (3) degree of enhancement in the portal venous phase (DEPP), (4) CT attenuation value of portal venous phase minus arterial phase (CTV-CTA), (5) enhanced potentiality (EP), (6) location, (7) contour, (8) growth pattern, (9) necrosis, (10) surface ulceration, (11) enlarged lymph node (LN). LR (M1), RF, DT, and GBDT models contained all of the above 11 variables, while LR (M2) was developed using six most predictive variables derived from (M1). LR (M2) model with AUC of 0.967 in test dataset was thought to be optimal model in differentiating the two tumors. Location in gastric body, exophytic and mixed growth pattern, lack of necrosis and surface ulceration, enlarged lymph nodes, and larger EP were the most important CT features suggestive of schwannomas. CONCLUSION: LR (M2) provided the optimal diagnostic potency among other ML versions, multivariate analysis, and radiologists' performance on differentiation of schwannomas from GISTs.
Authors: Paul Windisch; Carole Koechli; Susanne Rogers; Christina Schröder; Robert Förster; Daniel R Zwahlen; Stephan Bodis Journal: Cancers (Basel) Date: 2022-05-27 Impact factor: 6.575