Luisa Agnello1, Bruna Lo Sasso1,2, Rosaria Vincenza Giglio1, Giulia Bivona1, Caterina Maria Gambino1, Andrea Cortegiani3, Anna Maria Ciaccio4, Matteo Vidali5, Marcello Ciaccio1,2. 1. Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Laboratory Medicine, University of Palermo, Palermo, Italy. 2. Department of Laboratory Medicine, University Hospital "P. Giaccone", Palermo, Italy. 3. Division of Anaesthesia, Analgesia, Intensive Care and Emergency, Department of Surgical, Oncological and Oral Science, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy. 4. Unit of Clinical Biochemistry, University of Palermo, Palermo, Italy. 5. Unit of Clinical Chemistry, Maggiore della Carità Hospital, Novara, Italy.
Abstract
BACKGROUND: Monocyte distribution width has been recently proposed as a sepsis biomarker in the emergency department. The aim of this study was to assess the role of monocyte distribution width as a diagnostic biomarker of sepsis in the intensive care unit. METHODS: In this prospective observational study, we included all consecutive patients admitted to the intensive care unit of the University Hospital "P. Giaccone" of Palermo. Patients were classified into three groups according to Sepsis-3 criteria: (1) patients without sepsis; (2) patients developing sepsis during their hospital stay; (3) patients admitted with sepsis. Monocyte distribution width was measured at admission (groups 1, 2, 3) and daily until the developing of sepsis (group 2) or the end of hospitalization (group 1). RESULTS: Monocyte distribution width was significantly higher in group 3 than group 1 and group 2 (30.9 [25.6-36.0] vs. 20.3 [18.3-23.6] and 21.4 [19.4-25.2]). Among patients belonging to group 2, monocyte distribution width values, measured at the day when sepsis was clinically diagnosed, were significantly higher than those found at admission: 29.4 (26.7-36.0) vs. 21.4 (19.4-25.2), P = 0.001. CONCLUSION: Monocyte distribution width could represent a reliable biomarker of sepsis in the intensive care unit.
BACKGROUND: Monocyte distribution width has been recently proposed as a sepsis biomarker in the emergency department. The aim of this study was to assess the role of monocyte distribution width as a diagnostic biomarker of sepsis in the intensive care unit. METHODS: In this prospective observational study, we included all consecutive patients admitted to the intensive care unit of the University Hospital "P. Giaccone" of Palermo. Patients were classified into three groups according to Sepsis-3 criteria: (1) patients without sepsis; (2) patients developing sepsis during their hospital stay; (3) patients admitted with sepsis. Monocyte distribution width was measured at admission (groups 1, 2, 3) and daily until the developing of sepsis (group 2) or the end of hospitalization (group 1). RESULTS: Monocyte distribution width was significantly higher in group 3 than group 1 and group 2 (30.9 [25.6-36.0] vs. 20.3 [18.3-23.6] and 21.4 [19.4-25.2]). Among patients belonging to group 2, monocyte distribution width values, measured at the day when sepsis was clinically diagnosed, were significantly higher than those found at admission: 29.4 (26.7-36.0) vs. 21.4 (19.4-25.2), P = 0.001. CONCLUSION: Monocyte distribution width could represent a reliable biomarker of sepsis in the intensive care unit.
Authors: Titus A P de Hond; Wout J Hamelink; Mark C H de Groot; Imo E Hoefer; Jan Jelrik Oosterheert; Saskia Haitjema; Karin A H Kaasjager Journal: PLoS One Date: 2022-07-11 Impact factor: 3.752