| Literature DB >> 33074115 |
Zheng-Biao Zou1, Gang Zhang2, Su-Mei Li3, Zhi-Hui He1, Qing-Xiang Yan1, Yu-Kun Lin1, Chun-Lan Xie1, Jin-Mei Xia1, Zhu-Hua Luo1, Lian-Zhong Luo4, Xian-Wen Yang5.
Abstract
Ten new C9 polyketides (asperochratides A-J, 1-10) and 14 known miscellaneous compounds (11-24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher's method, Mo2(OAc)4 induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1-11 and 16-18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5-8 and 13-17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities.Entities:
Keywords: Aspergillus ochraceus; Deep-sea; Fungus; Polyketides
Year: 2020 PMID： 33074115 DOI： 10.1016/j.bioorg.2020.104349
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275