Neha Gupta1, Ashita Kalaskar2, Ritesh Kalaskar3. 1. Department of Oral Medicine and Radiology, Post-graduate Student, Government Dental College and Hospital, Nagpur, India. 2. Department of Oral Medicine and Radiology, Associate Professor, Government Dental College and Hospital, Nagpur, India. 3. Department of Pediatric Dentistry, Professor, Government Dental College and Hospital, Nagpur, India.
Abstract
PURPOSE: To evaluate the efficacy of lycopene in the management of Oral Submucous Fibrosis (OSMF). STUDY DESIGN: A comprehensive search was done in MEDLINE via PubMed, Cochrane, EBSCO-host and Google scholar from July 31st, 1999 to July 31st, 2019 to identify OSMF related clinical trials (Randomized and Non-randomized) involving lycopene as one of the intervention. RESULTS: 16 randomized control trials and 3 non-randomized control trials comprising 1181 subjects were included. The results of meta-analysis showed non-significant differences between lycopene and other interventions used in the treatment of OSMF. CONCLUSION: The present review suggests that lycopene is a safe and equally effective therapeutic modality as compared to other interventions for patients with OSMF. Further well-designed clinical trials are required to accurately assess the effectiveness of lycopene as compared to other medicinal treatments in the management of OSMF.
PURPOSE: To evaluate the efficacy of lycopene in the management of Oral Submucous Fibrosis (OSMF). STUDY DESIGN: A comprehensive search was done in MEDLINE via PubMed, Cochrane, EBSCO-host and Google scholar from July 31st, 1999 to July 31st, 2019 to identify OSMF related clinical trials (Randomized and Non-randomized) involving lycopene as one of the intervention. RESULTS: 16 randomized control trials and 3 non-randomized control trials comprising 1181 subjects were included. The results of meta-analysis showed non-significant differences between lycopene and other interventions used in the treatment of OSMF. CONCLUSION: The present review suggests that lycopene is a safe and equally effective therapeutic modality as compared to other interventions for patients with OSMF. Further well-designed clinical trials are required to accurately assess the effectiveness of lycopene as compared to other medicinal treatments in the management of OSMF.
Authors: Naman R Rao; Alessandro Villa; Chandramani B More; Ruwan D Jayasinghe; Alexander Ross Kerr; Newell W Johnson Journal: J Otolaryngol Head Neck Surg Date: 2020-01-08