Literature DB >> 33064809

Association Between Cytomegalovirus and Epstein-Barr Virus Viremia And Human Immunodeficiency Virus DNA Levels in the Reservoir of Kenyan Infants Receiving Antiretroviral Therapy.

Jennifer A Slyker1,2, Brandon Guthrie1,2, Mark Pankau1,3, Kenneth Tapia1, Dalton Wamalwa4, Sarah Benki-Nugent1, Evelyn Ngugi5, Meei-Li Huang6, Irene Njuguna1,2, Agnes Langat5, Grace John-Stewart1,2,7,8, Dara Lehman1,3.   

Abstract

Identifying determinants of human immunodeficiency virus (HIV) reservoir levels may inform novel viral eradication strategies. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) coinfections were assessed as predictors of HIV proviral DNA level in 26 HIV RNA-suppressed Kenyan children starting antiretroviral therapy before 7 months of age. Earlier acquisition of CMV and EBV and higher cumulative burden of systemic EBV DNA viremia were each associated with higher HIV DNA level in the reservoir after 24 months of antiretroviral therapy, independent of HIV RNA levels over time. These data suggest that delaying or containing CMV and EBV viremia may be novel strategies to limit HIV reservoir formation.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Cytomegalovirus; Epstein-Barr virus; HIV; HIV reservoir; pediatric

Mesh：

Substances：

Year:  2021        PMID： 33064809      PMCID： PMC8176631          DOI： 10.1093/infdis/jiaa640

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Vertical Cytomegalovirus Transmission From HIV-Infected Women Randomized to Formula-Feed or Breastfeed Their Infants.

Authors:  Barbra A Richardson; Grace John-Stewart; Claire Atkinson; Ruth Nduati; Kristjana Ásbjörnsdóttir; Michael Boeckh; Julie Overbaugh; Vincent Emery; Jennifer A Slyker
Journal:  J Infect Dis       Date:  2015-10-30       Impact factor: 5.226

2.  Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.

Authors:  Jennifer A Slyker; Sarah L Rowland-Jones; Tao Dong; Marie Reilly; Barbra Richardson; Vincent C Emery; Ann Atzberger; Dorothy Mbori-Ngacha; Barbara L Lohman-Payne; Grace C John-Stewart
Journal:  J Virol       Date:  2012-08-08       Impact factor: 5.103

3.  Treatment interruption after 2-year antiretroviral treatment initiated during acute/early HIV in infancy.

Authors:  Dalton Wamalwa; Sarah Benki-Nugent; Agnes Langat; Kenneth Tapia; Evelyn Ngugi; Helen Moraa; Elizabeth Maleche-Obimbo; Vincent Otieno; Irene Inwani; Barbra A Richardson; Bhavna Chohan; Julie Overbaugh; Grace C John-Stewart
Journal:  AIDS       Date:  2016-09-24       Impact factor: 4.177

4.  Molecular interactions of cytomegalovirus and the human and simian immunodeficiency viruses.

Authors:  P A Barry; E Pratt-Lowe; R E Unger; M Marthas; D J Alcendor; P A Luciw
Journal:  J Med Primatol       Date:  1990       Impact factor: 0.667

5.  Cytomegalovirus activates transcription directed by the long terminal repeat of human immunodeficiency virus type 1.

Authors:  P A Barry; E Pratt-Lowe; B M Peterlin; P A Luciw
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

6.  Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.

Authors:  Dalton Wamalwa; Sarah Benki-Nugent; Agnes Langat; Ken Tapia; Evelyn Ngugi; Jennifer A Slyker; Barbra A Richardson; Grace C John-Stewart
Journal:  Pediatr Infect Dis J       Date:  2012-07       Impact factor: 2.129

7.  Clinical and virologic manifestations of primary Epstein-Barr virus (EBV) infection in Kenyan infants born to HIV-infected women.

Authors:  Jennifer A Slyker; Corey Casper; Kenneth Tapia; Barbra Richardson; Lisa Bunts; Meei-Li Huang; Elizabeth Maleche-Obimbo; Ruth Nduati; Grace John-Stewart
Journal:  J Infect Dis       Date:  2013-03-14       Impact factor: 5.226

8.  Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants.

Authors:  Miguel A Garcia-Knight; Eunice Nduati; Amin S Hassan; Irene Nkumama; Timothy J Etyang; Naseem J Hajj; Faith Gambo; Denis Odera; James A Berkley; Sarah L Rowland-Jones; Britta Urban
Journal:  AIDS       Date:  2017-08-24       Impact factor: 4.177

9.  Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.

Authors:  Elisabeth Amyes; Chris Hatton; Damien Montamat-Sicotte; Nancy Gudgeon; Alan B Rickinson; Andrew J McMichael; Margaret F C Callan
Journal:  J Exp Med       Date:  2003-09-15       Impact factor: 14.307

10.  A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.

Authors:  Katherine M Bruner; Zheng Wang; Francesco R Simonetti; Alexandra M Bender; Kyungyoon J Kwon; Srona Sengupta; Emily J Fray; Subul A Beg; Annukka A R Antar; Katharine M Jenike; Lynn N Bertagnolli; Adam A Capoferri; Joshua T Kufera; Andrew Timmons; Christopher Nobles; John Gregg; Nikolas Wada; Ya-Chi Ho; Hao Zhang; Joseph B Margolick; Joel N Blankson; Steven G Deeks; Frederic D Bushman; Janet D Siliciano; Gregory M Laird; Robert F Siliciano
Journal:  Nature       Date:  2019-01-30       Impact factor: 49.962
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  2 in total

1.  Preservation of lymphocyte functional fitness in perinatally-infected and treated HIV+ pediatric patients displaying sub-optimal viral control.

Authors:  Aaruni Khanolkar; William J Muller; Bridget M Simpson; Jillian Cerullo; Ruth Williams; Sun Bae Sowers; Kiana Matthews; Sara Mercader; Carole J Hickman; Richard T D'Aquila; Guorong Liu
Journal:  Commun Med (Lond)       Date:  2022-03-04

2.  Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda.

Authors:  Samira Joussef-Piña; Immaculate Nankya; Sophie Nalukwago; Joy Baseke; Sandra Rwambuya; Dane Winner; Fred Kyeyune; Keith Chervenak; Bonnie Thiel; Robert Asaad; Curtis Dobrowolski; Benjamin Luttge; Blair Lawley; Cissy M Kityo; W Henry Boom; Jonathan Karn; Miguel E Quiñones-Mateu
Journal:  Retrovirology       Date:  2022-01-15       Impact factor: 4.602
  2 in total

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