Literature DB >> 22544051

Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.

Dalton Wamalwa1, Sarah Benki-Nugent, Agnes Langat, Ken Tapia, Evelyn Ngugi, Jennifer A Slyker, Barbra A Richardson, Grace C John-Stewart.   

Abstract

Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.

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Year:  2012        PMID： 22544051      PMCID： PMC3756892          DOI： 10.1097/INF.0b013e3182587796

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  9 in total

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Authors:  Dalton C Wamalwa; Carey Farquhar; Elizabeth M Obimbo; Sara Selig; Dorothy A Mbori-Ngacha; Barbra A Richardson; Julie Overbaugh; Sandy Emery; Grace Wariua; Christine Gichuhi; Rose Bosire; Grace John-Stewart
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Authors:  JoAnna K Leyenaar; Paul M Novosad; Katheleen T Ferrer; Lineo K Thahane; Edith Q Mohapi; Gordon E Schutze; Mark W Kline
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Authors:  Steven F J Callens; Nicole Shabani; Jean Lusiama; Patricia Lelo; Faustin Kitetele; Robert Colebunders; Ziya Gizlice; Andrew Edmonds; Annelies Van Rie; Frieda Behets
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Authors:  Avy Violari; Mark F Cotton; Diana M Gibb; Abdel G Babiker; Jan Steyn; Shabir A Madhi; Patrick Jean-Philippe; James A McIntyre
Journal:  N Engl J Med       Date:  2008-11-20       Impact factor: 91.245
  9 in total
  29 in total

1.  Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa.

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Journal:  J Acquir Immune Defic Syndr       Date:  2014-04-15       Impact factor: 3.731

2.  Nevirapine Resistance in Previously Nevirapine-Unexposed HIV-1-Infected Kenyan Infants Initiating Early Antiretroviral Therapy.

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4.  Correlates of age at attainment of developmental milestones in HIV-infected infants receiving early antiretroviral therapy.

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5.  Differences in virologic and immunologic response to antiretroviral therapy among HIV-1-infected infants and children.

Authors:  Kristjana H Ásbjörnsdóttir; James P Hughes; Dalton Wamalwa; Agnes Langat; Jennifer A Slyker; Hellen M Okinyi; Julie Overbaugh; Sarah Benki-Nugent; Kenneth Tapia; Elizabeth Maleche-Obimbo; Ali Rowhani-Rahbar; Grace John-Stewart
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8.  Predictors of Early ART Initiation Among HIV + Infants in Kenya: A Retrospective Review of HITSystem Data from 2013 to 2017.

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9.  Accelerated suppression of primary Epstein-Barr virus infection in HIV-infected infants initiating lopinavir/ritonavir-based versus nevirapine-based combination antiretroviral therapy.

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10.  Compartmentalized cytomegalovirus replication and transmission in the setting of maternal HIV-1 infection.

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