Weiming Liu1, Chunmin Wang2, Yu Xia2, Wei Xia1, Gaoqin Liu1,3, Chi Ren1, Yu Gu1, Xin Li1, Peirong Lu4,5. 1. Department of Ophthalmology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, People's Republic of China. 2. Suzhou Center for Disease Control and Prevention, 72 Sanxiang Road, Suzhou, 215004, People's Republic of China. 3. Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 708 Renmin Road, Suzhou, 215006, People's Republic of China. 4. Department of Ophthalmology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, People's Republic of China. lupeirong@suda.edu.cn. 5. Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 708 Renmin Road, Suzhou, 215006, People's Republic of China. lupeirong@suda.edu.cn.
Abstract
AIMS: To determine the relationship between plasma levels of trimethylamine-N-oxide (TMAO) and odds of diabetic retinopathy (DR). METHODS: A cross-sectional study was conducted. Blood samples were obtained from 122 type 2 diabetes mellitus (T2DM) patients with or without DR. Multivariable logistic regression analyses were performed to identify the association between plasma TMAO and DR. The diagnostic value of plasma TMAO was assessed by the area under the receiver operating characteristic curve (AUROC) and integrated discrimination improvement (IDI). RESULTS: In the T2DM patients, plasma levels of TMAO were significantly higher in patients with DR compared with those without DR (P = 0.001). As logarithmic (ln) transformation of TMAO increased per standard deviation (SD), there was higher probability to have DR [odds ratio (OR) = 2.31; P = 0.005]. As ln-transformed TMAO increased per SD, the severity of DR was more likely to get worse (OR = 2.05; P = 0.004). In the diagnostic model, the addition of TMAO contributed to the improvement in AUROC from 0.646 to 0.734 (P = 0.043), and the IDI was 10.7% (P < 0.001). CONCLUSION: Elevated levels of plasma TMAO were associated with higher odds and worse severity of DR in T2DM patients, and further investigation is required for the causality of this association.
AIMS: To determine the relationship between plasma levels of trimethylamine-N-oxide (TMAO) and odds of diabetic retinopathy (DR). METHODS: A cross-sectional study was conducted. Blood samples were obtained from 122 type 2 diabetes mellitus (T2DM) patients with or without DR. Multivariable logistic regression analyses were performed to identify the association between plasma TMAO and DR. The diagnostic value of plasma TMAO was assessed by the area under the receiver operating characteristic curve (AUROC) and integrated discrimination improvement (IDI). RESULTS: In the T2DM patients, plasma levels of TMAO were significantly higher in patients with DR compared with those without DR (P = 0.001). As logarithmic (ln) transformation of TMAO increased per standard deviation (SD), there was higher probability to have DR [odds ratio (OR) = 2.31; P = 0.005]. As ln-transformed TMAO increased per SD, the severity of DR was more likely to get worse (OR = 2.05; P = 0.004). In the diagnostic model, the addition of TMAO contributed to the improvement in AUROC from 0.646 to 0.734 (P = 0.043), and the IDI was 10.7% (P < 0.001). CONCLUSION: Elevated levels of plasma TMAO were associated with higher odds and worse severity of DR in T2DM patients, and further investigation is required for the causality of this association.
Entities:
Keywords:
Diabetic retinopathy; Gut microbiome; Metabolite; TMAO; Trimethylamine-N-oxide; Type 2 diabetes mellitus
Authors: Zeneng Wang; Adam B Roberts; Jennifer A Buffa; Bruce S Levison; Weifei Zhu; Elin Org; Xiaodong Gu; Ying Huang; Maryam Zamanian-Daryoush; Miranda K Culley; Anthony J DiDonato; Xiaoming Fu; Jennie E Hazen; Daniel Krajcik; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen Journal: Cell Date: 2015-12-17 Impact factor: 41.582
Authors: Christina J Flaxel; Ron A Adelman; Steven T Bailey; Amani Fawzi; Jennifer I Lim; G Atma Vemulakonda; Gui-Shuang Ying Journal: Ophthalmology Date: 2019-09-25 Impact factor: 12.079
Authors: Yoriko Heianza; Dianjianyi Sun; Xiang Li; Joseph A DiDonato; George A Bray; Frank M Sacks; Lu Qi Journal: Gut Date: 2018-06-02 Impact factor: 23.059
Authors: Diana M Shih; Weifei Zhu; Rebecca C Schugar; Yonghong Meng; Xun Jia; Aika Miikeda; Zeneng Wang; Marina Zieger; Richard Lee; Mark Graham; Hooman Allayee; Rita M Cantor; Christian Mueller; J Mark Brown; Stanley L Hazen; Aldons J Lusis Journal: Arterioscler Thromb Vasc Biol Date: 2019-06 Impact factor: 8.311
Authors: Gabriele Giacomo Schiattarella; Anna Sannino; Evelina Toscano; Giuseppe Giugliano; Giuseppe Gargiulo; Anna Franzone; Bruno Trimarco; Giovanni Esposito; Cinzia Perrino Journal: Eur Heart J Date: 2017-10-14 Impact factor: 29.983
Authors: Adam B Roberts; Xiaodong Gu; Jennifer A Buffa; Alex G Hurd; Zeneng Wang; Weifei Zhu; Nilaksh Gupta; Sarah M Skye; David B Cody; Bruce S Levison; William T Barrington; Matthew W Russell; Jodie M Reed; Ashraf Duzan; Jennifer M Lang; Xiaoming Fu; Lin Li; Alex J Myers; Suguna Rachakonda; Joseph A DiDonato; J Mark Brown; Valentin Gogonea; Aldons J Lusis; Jose Carlos Garcia-Garcia; Stanley L Hazen Journal: Nat Med Date: 2018-08-06 Impact factor: 53.440