| Literature DB >> 33060197 |
David E Gordon1,2,3,4, Joseph Hiatt1,4,5,6,7, Mehdi Bouhaddou1,2,3,4, Veronica V Rezelj8, Svenja Ulferts9, Hannes Braberg1,2,3,4, Alexander S Jureka10, Kirsten Obernier1,2,3,4, Jeffrey Z Guo1,2,3,4, Jyoti Batra1,2,3,4, Robyn M Kaake1,2,3,4, Andrew R Weckstein11, Tristan W Owens12, Meghna Gupta12, Sergei Pourmal12, Erron W Titus12, Merve Cakir1,2,3,4, Margaret Soucheray1,2,3,4, Michael McGregor1,2,3,4, Zeynep Cakir1,2,3,4, Gwendolyn Jang1,2,3,4, Matthew J O'Meara13, Tia A Tummino1,2,14, Ziyang Zhang1,2,3,15, Helene Foussard1,2,3,4, Ajda Rojc1,2,3,4, Yuan Zhou1,2,3,4, Dmitry Kuchenov1,2,3,4, Ruth Hüttenhain1,2,3,4, Jiewei Xu1,2,3,4, Manon Eckhardt1,2,3,4, Danielle L Swaney1,2,3,4, Jacqueline M Fabius1,2, Manisha Ummadi1,2,3,4, Beril Tutuncuoglu1,2,3,4, Ujjwal Rathore1,2,3,4, Maya Modak1,2,3,4, Paige Haas1,2,3,4, Kelsey M Haas1,2,3,4, Zun Zar Chi Naing1,2,3,4, Ernst H Pulido1,2,3,4, Ying Shi1,2,3,15, Inigo Barrio-Hernandez16, Danish Memon16, Eirini Petsalaki16, Alistair Dunham16, Miguel Correa Marrero16, David Burke16, Cassandra Koh8, Thomas Vallet8, Jesus A Silvas10, Caleigh M Azumaya12, Christian Billesbølle12, Axel F Brilot12, Melody G Campbell12,17, Amy Diallo12, Miles Sasha Dickinson12, Devan Diwanji12, Nadia Herrera12, Nick Hoppe12, Huong T Kratochvil12, Yanxin Liu12, Gregory E Merz12, Michelle Moritz12, Henry C Nguyen12, Carlos Nowotny12, Cristina Puchades12, Alexandrea N Rizo12, Ursula Schulze-Gahmen12, Amber M Smith12, Ming Sun12,18, Iris D Young12, Jianhua Zhao12, Daniel Asarnow12, Justin Biel12, Alisa Bowen12, Julian R Braxton12, Jen Chen12, Cynthia M Chio12, Un Seng Chio12, Ishan Deshpande12, Loan Doan12, Bryan Faust12, Sebastian Flores12, Mingliang Jin12, Kate Kim12, Victor L Lam12, Fei Li12, Junrui Li12, Yen-Li Li12, Yang Li12, Xi Liu12, Megan Lo12, Kyle E Lopez12, Arthur A Melo12, Frank R Moss12, Phuong Nguyen12, Joana Paulino12, Komal Ishwar Pawar12, Jessica K Peters12, Thomas H Pospiech12, Maliheh Safari12, Smriti Sangwan12, Kaitlin Schaefer12, Paul V Thomas12, Aye C Thwin12, Raphael Trenker12, Eric Tse12, Tsz Kin Martin Tsui12, Feng Wang12, Natalie Whitis12, Zanlin Yu12, Kaihua Zhang12, Yang Zhang12, Fengbo Zhou12, Daniel Saltzberg1,2,19, Anthony J Hodder20, Amber S Shun-Shion20, Daniel M Williams20, Kris M White21,22, Romel Rosales21,22, Thomas Kehrer21,22, Lisa Miorin21,22, Elena Moreno21,22, Arvind H Patel23, Suzannah Rihn23, Mir M Khalid4, Albert Vallejo-Gracia4, Parinaz Fozouni4,5,7, Camille R Simoneau4,7, Theodore L Roth5,6,7, David Wu5,7, Mohd Anisul Karim24,25, Maya Ghoussaini24,25, Ian Dunham16,25, Francesco Berardi26, Sebastian Weigang27, Maxime Chazal28, Jisoo Park29, James Logue30, Marisa McGrath30, Stuart Weston30, Robert Haupt30, C James Hastie31, Matthew Elliott31, Fiona Brown31, Kerry A Burness31, Elaine Reid31, Mark Dorward31, Clare Johnson31, Stuart G Wilkinson31, Anna Geyer31, Daniel M Giesel31, Carla Baillie31, Samantha Raggett31, Hannah Leech31, Rachel Toth31, Nicola Goodman31, Kathleen C Keough4, Abigail L Lind4, Reyna J Klesh32, Kafi R Hemphill33, Jared Carlson-Stevermer34, Jennifer Oki34, Kevin Holden34, Travis Maures34, Katherine S Pollard4,35,36, Andrej Sali1,2,14,19, David A Agard1,2,12,37, Yifan Cheng1,2,12,15,37, James S Fraser1,2,12,19, Adam Frost1,2,12,37, Natalia Jura1,2,3,12,38, Tanja Kortemme1,2,12,19,39, Aashish Manglik1,2,12,14, Daniel R Southworth1,12,37, Robert M Stroud1,2,12,37, Dario R Alessi31, Paul Davies31, Matthew B Frieman30, Trey Ideker29,40, Carmen Abate26, Nolwenn Jouvenet27,28, Georg Kochs27, Brian Shoichet1,2,14, Melanie Ott4,41, Massimo Palmarini23, Kevan M Shokat1,2,3,15, Adolfo García-Sastre42,22,43,44, Jeremy A Rassen45, Robert Grosse46,47, Oren S Rosenberg48,2,12,36,37,41, Kliment A Verba48,2,12,14, Christopher F Basler49, Marco Vignuzzi50, Andrew A Peden51, Pedro Beltrao52, Nevan J Krogan48,2,3,4,21.
Abstract
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study.Entities:
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Year: 2020 PMID： 33060197 PMCID： PMC7808408 DOI： 10.1126/science.abe9403
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728