Literature DB >> 3305075

Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells.

T Andus, T Geiger, T Hirano, H Northoff, U Ganter, J Bauer, T Kishimoto, P C Heinrich.   

Abstract

Conditioned medium from human monocytes contains a partially characterized hepatocyte-stimulating factor that simultaneously elevates the mRNA levels of the acute-phase protein beta-fibrinogen and decreases albumin mRNA in rat hepatoma cells. We demonstrate that recombinant human B-cell stimulatory factor 2, which is identical to interferon-beta 2/26 kDa protein and interleukin-HP1, exhibits the same activity as hepatocyte-stimulating factor. Furthermore, a specific antibody against B-cell stimulatory factor 2 was able to inhibit hepatocyte-stimulating factor in conditioned medium from human monocytes. Our data show that hepatocyte-stimulating factor and B-cell stimulatory factor 2 are functionally and immunologically related proteins.

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Year:  1987        PMID： 3305075     DOI： 10.1016/0014-5793(87)80344-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  62 in total

1.  Characterization of recombinant cytokine fragments using isotachophoresis-capillary zone electrophoresis, reversed-phase high performance liquid chromatography, and mass spectrometry.

Authors:  J Gysler; B Helk; S Dambacher; U R Tjaden; J van der Greef
Journal:  Pharm Res       Date:  1999-05       Impact factor: 4.200

2.  Interleukin-6 is antiproliferative to a mouse hybridoma cell line and promotive for its antibody productivity.

Authors:  F Makishima; S Terada; T Mikami; E Suzuki
Journal:  Cytotechnology       Date:  1992       Impact factor: 2.058

3.  Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

Authors:  T Taga; M Narazaki; K Yasukawa; T Saito; D Miki; M Hamaguchi; S Davis; M Shoyab; G D Yancopoulos; T Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

4.  A critical role of the transcription factor fli-1 in murine lupus development by regulation of interleukin-6 expression.

Authors:  Shuzo Sato; Mara Lennard Richard; Danielle Brandon; Joy N Jones Buie; Jim C Oates; Gary S Gilkeson; Xian K Zhang
Journal:  Arthritis Rheumatol       Date:  2014-12       Impact factor: 10.995

Review 5.  Interleukin-6 and the acute phase response.

Authors:  P C Heinrich; J V Castell; T Andus
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

Review 6.  [Hepatology. New research results in its significance for the understanding of liver diseases].

Authors:  W Gerok; H E Blum; W Offensperger; S Offensperger; T Andus; V Gross; P C Heinrich
Journal:  Naturwissenschaften       Date:  1991-06

Review 7.  Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody.

Authors:  K Yoshizaki; N Nishimoto; M Mihara; T Kishimoto
Journal:  Springer Semin Immunopathol       Date:  1998

8.  Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

Authors:  C P Chiu; C Moulds; R L Coffman; D Rennick; F Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

9.  Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

Authors:  J M Le; G Fredrickson; L F Reis; T Diamantstein; T Hirano; T Kishimoto; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

Review 10.  Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine.

Authors:  M Revel
Journal:  Experientia       Date:  1989-06-15
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