Literature DB >> 33046495

Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice.

Harindra D Sathkumara1, Karyna Hansen1, Socorro Miranda-Hernandez1, Brenda Govan1,2, Catherine M Rush1,2, Lars Henning2, Natkunam Ketheesan3, Andreas Kupz4.   

Abstract

Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  diabetes; host-directed therapy; metformin; tuberculosis

Year:  2020        PMID： 33046495      PMCID： PMC7927854          DOI： 10.1128/AAC.01422-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

Authors:  Navdeep S Chandel; Dania Avizonis; Colleen R Reczek; Samuel E Weinberg; Stephan Menz; Roland Neuhaus; Sven Christian; Andrea Haegebarth; Carolyn Algire; Michael Pollak
Journal:  Cell Metab       Date:  2016-04-12       Impact factor: 27.287

2.  Reduced prevalence of latent tuberculosis infection in diabetes patients using metformin and statins.

Authors:  Matthew J Magee; Argita D Salindri; Hardy Kornfeld; Amit Singhal
Journal:  Eur Respir J       Date:  2019-03-14       Impact factor: 16.671

3.  Metformin as adjunct antituberculosis therapy.

Authors:  Amit Singhal; Liu Jie; Pavanish Kumar; Gan Suay Hong; Melvin Khee-Shing Leow; Bhairav Paleja; Liana Tsenova; Natalia Kurepina; Jinmiao Chen; Francesca Zolezzi; Barry Kreiswirth; Michael Poidinger; Cynthia Chee; Gilla Kaplan; Yee Tang Wang; Gennaro De Libero
Journal:  Sci Transl Med       Date:  2014-11-19       Impact factor: 17.956

4.  Age-related differences in pulmonary cytokine response to respiratory syncytial virus infection: modulation by anti-inflammatory and antiviral treatment.

Authors:  Marina S Boukhvalova; Kevin C Yim; Katie H Kuhn; John P Hemming; Gregory A Prince; David D Porter; Jorge C G Blanco
Journal:  J Infect Dis       Date:  2007-01-04       Impact factor: 5.226

5.  Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.

Authors:  Catherine W M Ong; Paul T Elkington; Sara Brilha; Cesar Ugarte-Gil; Maite T Tome-Esteban; Liku B Tezera; Przemyslaw J Pabisiak; Rachel C Moores; Tarangini Sathyamoorthy; Vimal Patel; Robert H Gilman; Joanna C Porter; Jon S Friedland
Journal:  PLoS Pathog       Date:  2015-05-21       Impact factor: 6.823

Review 6.  Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma.

Authors:  Heather L Thompson; Megan J Smithey; Charles D Surh; Janko Nikolich-Žugich
Journal:  Front Immunol       Date:  2017-06-14       Impact factor: 7.561

7.  Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its Potential Role in Gut Microbiota Homeostasis.

Authors:  Wei Ma; Ji Chen; Yuhong Meng; Jichun Yang; Qinghua Cui; Yuan Zhou
Journal:  Front Microbiol       Date:  2018-06-22       Impact factor: 5.640

8.  Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis.

Authors:  Balewgizie Sileshi Tegegne; Melkamu Merid Mengesha; Andreas A Teferra; Mamaru Ayenew Awoke; Tesfa Dejenie Habtewold
Journal:  Syst Rev       Date:  2018-10-15

9.  Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects.

Authors:  Ekta Lachmandas; Clare Eckold; Julia Böhme; Valerie A C M Koeken; Mardiana Binte Marzuki; Bastiaan Blok; Rob J W Arts; Jinmiao Chen; Karen W W Teng; Jacqueline Ratter; Elise J Smolders; Corina Van den Heuvel; Rinke Stienstra; Hazel M Dockrell; Evan Newell; Mihai G Netea; Amit Singhal; Jacqueline M Cliff; Reinout Van Crevel
Journal:  J Infect Dis       Date:  2019-06-05       Impact factor: 5.226

10.  The Host Microbiota Contributes to Early Protection Against Lung Colonization by Mycobacterium tuberculosis.

Authors:  Alexia Dumas; Dan Corral; André Colom; Florence Levillain; Antonio Peixoto; Denis Hudrisier; Yannick Poquet; Olivier Neyrolles
Journal:  Front Immunol       Date:  2018-11-14       Impact factor: 7.561
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  3 in total

Review 1.  Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia.

Authors:  Minh Dao Ngo; Stacey Bartlett; Katharina Ronacher
Journal:  Microorganisms       Date:  2021-11-02

Review 2.  Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity.

Authors:  Amnah Al-Sayyar; Katina D Hulme; Ronan Thibaut; Jagadeesh Bayry; Frederick J Sheedy; Kirsty R Short; Fawaz Alzaid
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-26       Impact factor: 6.055

3.  A murine model of tuberculosis/type 2 diabetes comorbidity for investigating the microbiome, metabolome and associated immune parameters.

Authors:  Harindra D Sathkumara; Janet L Eaton; Matt A Field; Brenda L Govan; Natkunam Ketheesan; Andreas Kupz
Journal:  Animal Model Exp Med       Date:  2021-03-23
  3 in total

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