Hannah Gardener1, Qi Sun2, Philippe Grandjean3. 1. University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: hgardener@med.miami.edu. 2. Harvard TH Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, USA. 3. Harvard TH Chan School of Public Health, Boston, MA, USA; University of Southern Denmark, Odense, Denmark.
Abstract
INTRODUCTION: Poly- and perfluoroalkyl substances (PFAS) are persistent organic pollutants with pervasive exposure and suspected associations with metabolic abnormalities and adverse pregnancy outcomes. The goal of the present study was to examine the relationship between serum-PFAS concentrations measured in late pregnancy with relevant outcomes. METHODS: The study sample included 433 pregnant women enrolled in the Vanguard Pilot Study of the National Children's Study. Six PFAS were measured in primarily third trimester serum, as well as fasting insulin, total cholesterol, and triglycerides. The PFAS were examined in quartiles in relation to serum biomarkers, gestational age at birth and birth weight standardized for gestational age using multivariable-adjusted regression models. RESULTS: Over 98% of the study population had detectable concentrations of four of the PFAS, and concentrations varied by race/ethnicity. Total cholesterol was positively associated with PFDA, PFNA, and PFOS, and triglycerides with PFDA, PFNA, PFOS, and PFOA, but PFAS were not associated with fasting insulin in adjusted models. Only PFNA was associated with an increased odds of birth at <37 weeks gestation. PFAS were generally not associated with birth weight, though PFHxS was associated with the first quartile of birth weight among males only. CONCLUSIONS: This study of pregnant U.S. women supports the ubiquitous exposure to PFAS and positive associations between PFAS exposure with serum-lipid concentrations. PFAS were largely unassociated with gestational age at birth and birth weight, though PFNA was associated with preterm birth. The results support the vulnerability to PFAS exposure of pregnancy.
INTRODUCTION: Poly- and perfluoroalkyl substances (PFAS) are persistent organic pollutants with pervasive exposure and suspected associations with metabolic abnormalities and adverse pregnancy outcomes. The goal of the present study was to examine the relationship between serum-PFAS concentrations measured in late pregnancy with relevant outcomes. METHODS: The study sample included 433 pregnant women enrolled in the Vanguard Pilot Study of the National Children's Study. Six PFAS were measured in primarily third trimester serum, as well as fasting insulin, total cholesterol, and triglycerides. The PFAS were examined in quartiles in relation to serum biomarkers, gestational age at birth and birth weight standardized for gestational age using multivariable-adjusted regression models. RESULTS: Over 98% of the study population had detectable concentrations of four of the PFAS, and concentrations varied by race/ethnicity. Total cholesterol was positively associated with PFDA, PFNA, and PFOS, and triglycerides with PFDA, PFNA, PFOS, and PFOA, but PFAS were not associated with fasting insulin in adjusted models. Only PFNA was associated with an increased odds of birth at <37 weeks gestation. PFAS were generally not associated with birth weight, though PFHxS was associated with the first quartile of birth weight among males only. CONCLUSIONS: This study of pregnant U.S. women supports the ubiquitous exposure to PFAS and positive associations between PFAS exposure with serum-lipid concentrations. PFAS were largely unassociated with gestational age at birth and birth weight, though PFNA was associated with preterm birth. The results support the vulnerability to PFAS exposure of pregnancy.
Authors: Damaskini Valvi; Youssef Oulhote; Pal Weihe; Christine Dalgård; Kristian S Bjerve; Ulrike Steuerwald; Philippe Grandjean Journal: Environ Int Date: 2017-07-25 Impact factor: 9.621
Authors: Cyntia B Manzano-Salgado; Maribel Casas; Maria-Jose Lopez-Espinosa; Ferran Ballester; Carmen Iñiguez; David Martinez; Olga Costa; Loreto Santa-Marina; Eva Pereda-Pereda; Thomas Schettgen; Jordi Sunyer; Martine Vrijheid Journal: Environ Int Date: 2017-11 Impact factor: 9.621
Authors: Stephanie J Frisbee; Anoop Shankar; Sarah S Knox; Kyle Steenland; David A Savitz; Tony Fletcher; Alan M Ducatman Journal: Arch Pediatr Adolesc Med Date: 2010-09
Authors: Anne P Starling; John L Adgate; Richard F Hamman; Katerina Kechris; Antonia M Calafat; Dana Dabelea Journal: Environ Int Date: 2019-07-05 Impact factor: 9.621
Authors: Antonia M Calafat; Kayoko Kato; Kendra Hubbard; Tao Jia; Julianne Cook Botelho; Lee-Yang Wong Journal: Environ Int Date: 2019-07-31 Impact factor: 9.621
Authors: Gang Liu; Klodian Dhana; Jeremy D Furtado; Jennifer Rood; Geng Zong; Liming Liang; Lu Qi; George A Bray; Lilian DeJonge; Brent Coull; Philippe Grandjean; Qi Sun Journal: PLoS Med Date: 2018-02-13 Impact factor: 11.069
Authors: Peter K Gilbertson; Susan Forrester; Linda Andrews; Kathleen McCann; Lydia Rogers; Christina Park; Jack Moye Journal: Front Public Health Date: 2021-03-05
Authors: Mohammed Abdulhasan; Ximena Ruden; Yuan You; Sean M Harris; Douglas M Ruden; Awoniyi O Awonuga; Ayesha Alvero; Elizabeth E Puscheck; Daniel A Rappolee Journal: Front Toxicol Date: 2021-11-30
Authors: J J Schlezinger; T Hyötyläinen; T Sinioja; C Boston; H Puckett; J Oliver; W Heiger-Bernays; T F Webster Journal: Toxicol Appl Pharmacol Date: 2021-07-10 Impact factor: 4.460
Authors: Yun Jeong Lee; Hae Woon Jung; Hwa Young Kim; Yoon-Jung Choi; Young Ah Lee Journal: Front Endocrinol (Lausanne) Date: 2021-09-09 Impact factor: 5.555
Authors: M Abdul Mottaleb; Qunxing X Ding; Kelly G Pennell; Erin N Haynes; Andrew J Morris Journal: J Chromatogr A Date: 2021-07-21 Impact factor: 4.759