Alex Gu1, Amil Agarwal2, Safa C Fassihi2, Patawut Bovonratwet3, Joshua C Campbell2, Peter K Sculco4. 1. Department of Orthopaedic Surgery, George Washington University Hospital, Washington, DC; Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY. 2. Department of Orthopaedic Surgery, George Washington University Hospital, Washington, DC. 3. Department of Orthopedics, Hospital for Special Surgery, New York, NY. 4. Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY.
Abstract
BACKGROUND: Periprosthetic joint infection (PJI) is among the leading causes of failure in total joint arthroplasty. A recently proposed risk factor for PJI is symptomatic benign prostatic hyperplasia (sBPH). This study aims to determine if sBPH is associated with PJI following primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). METHODS: Using the Mariner all-payer claims database, 1745 patients with sBPH undergoing primary THA were propensity-matched with 3490 controls, and 3053 patients with sBPH undergoing primary TKA were propensity-matched with 6106 controls. Additionally, the same 1745 patients with sBPH undergoing THA were compared to 317,360 prematched controls, and the same 3053 patients with sBPH undergoing TKA were compared to 557,730 prematched controls. Univariate analysis was conducted using chi-squared or ANOVA where appropriate. RESULTS: At two years postoperatively, patients with sBPH were not at significantly increased risk for PJI following primary THA (1.54% vs 1.43%; P = .745) and TKA (1.99% vs 2.14%; P = .642) relative to postmatch controls. Compared to matched controls, THA patients with sBPH had an increased 90-day incidence of anemia (P < .001), blood transfusion (P < .001), and urinary tract infection (UTI; P < .001). Total knee arthroplasty patients with sBPH had an increased 90-day incidence of anemia (P < .001), blood transfusion (P < .001), cellulitis (P = .023), renal failure (P = .030), heart failure (P = .029), and UTI (P < .001) relative to matched controls. CONCLUSION: In primary THA and TKA, sBPH does not appear to be an independent risk factor for PJI within two years postoperatively. However, clinicians should be cognizant of the significantly increased risk for postoperative UTI in this patient population.
BACKGROUND: Periprosthetic joint infection (PJI) is among the leading causes of failure in total joint arthroplasty. A recently proposed risk factor for PJI is symptomatic benign prostatic hyperplasia (sBPH). This study aims to determine if sBPH is associated with PJI following primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). METHODS: Using the Mariner all-payer claims database, 1745 patients with sBPH undergoing primary THA were propensity-matched with 3490 controls, and 3053 patients with sBPH undergoing primary TKA were propensity-matched with 6106 controls. Additionally, the same 1745 patients with sBPH undergoing THA were compared to 317,360 prematched controls, and the same 3053 patients with sBPH undergoing TKA were compared to 557,730 prematched controls. Univariate analysis was conducted using chi-squared or ANOVA where appropriate. RESULTS: At two years postoperatively, patients with sBPH were not at significantly increased risk for PJI following primary THA (1.54% vs 1.43%; P = .745) and TKA (1.99% vs 2.14%; P = .642) relative to postmatch controls. Compared to matched controls, THA patients with sBPH had an increased 90-day incidence of anemia (P < .001), blood transfusion (P < .001), and urinary tract infection (UTI; P < .001). Total knee arthroplasty patients with sBPH had an increased 90-day incidence of anemia (P < .001), blood transfusion (P < .001), cellulitis (P = .023), renal failure (P = .030), heart failure (P = .029), and UTI (P < .001) relative to matched controls. CONCLUSION: In primary THA and TKA, sBPH does not appear to be an independent risk factor for PJI within two years postoperatively. However, clinicians should be cognizant of the significantly increased risk for postoperative UTI in this patient population.
Authors: Adam M Gordon; Keith B Diamond; Asad M Ashraf; Matthew L Magruder; Ramin Sadeghpour; Jack Choueka Journal: Eur J Orthop Surg Traumatol Date: 2022-08-11
Authors: Michael B Held; Anastasia Gazgalis; Alexander L Neuwirth; Roshan P Shah; H John Cooper; Jeffrey A Geller Journal: Knee Surg Sports Traumatol Arthrosc Date: 2021-05-07 Impact factor: 4.114
Authors: Reha N Tandogan; Nanne P Kort; Ersin Ercin; Floris van Rooij; Luca Nover; Mo Saffarini; Michael T Hirschmann; Roland Becker; David Dejour Journal: Knee Surg Sports Traumatol Arthrosc Date: 2021-03-01 Impact factor: 4.114