Literature DB >> 33029235

THE ROLE OF NT PRO-BNP IN THE EVALUATION OF DIABETIC PATIENTS WITH HEART FAILURE.

F I Fringu1, A V Sitar-Taut2, B Caloian3, D Zdrenghea1, D Comsa3, G Gusetu1, D Pop1,3.   

Abstract

CONTEXT: The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) is high.
OBJECTIVE: To analyze the role of NT-pro-BNP levels in the evaluation of diabetic patients with heart failure.
DESIGN: Retrospective comparative cohort study. SUBJECTS AND METHODS: A total of 174 patients admitted to our Cardiology Department, previously diagnosed with HF, were enrolled. Among these patients, 47.7% had DM. HF was defined according to the 2016 ESC criteria. The NT-pro BNP levels above 126 pg/mL indicate a high probability of heart failure.
RESULTS: In diabetic patients there were significant correlations between NT-pro-BNP values and the following parameters: hemoglobin (rho=-0.28, p=0.01), hematocrit (rho= -0.27, p=0.014), total cholesterol (rho= -0.21, p=0.048), triglycerides (rho= -0.283, p=0.01), ejection fraction (rho= -0.465, p<0.0001), end-diastolic volume (rho= 0.253, p= 0.026), end-systolic volume (rho= 0.29 p=0.01). Only the following 3 parameters: ejection fraction (p= 0.0009), hemoglobin (p= 0.0092) and triglycerides (p= 0.0380) were independent predictive factors for elevated NT-pro-BNP values.
CONCLUSION: In diabetic heart failure patients, the value of NT-pro-BNP holds a pivotal role in the evaluation of their overall status, facilitating the establishment of correct management and follow-up. ©by Acta Endocrinologica Foundation.

Entities:  

Keywords:  NT-pro-BNP; diabetes mellitus; heart failure

Year:  2020        PMID： 33029235      PMCID： PMC7535893          DOI： 10.4183/aeb.2020.183

Source DB:  PubMed          Journal:  Acta Endocrinol (Buchar)        ISSN： 1841-0987            Impact factor:   0.877


  37 in total

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9.  PONTIAC (NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease): a prospective randomized controlled trial.

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