Adela Viviana Sitar Taut1, Dana Pop2, Dumitru Tudor Zdrenghea3. 1. "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; "New Bluelife" Medical Center, Cluj-Napoca, Romania. Electronic address: adelasitar@yahoo.com. 2. "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Rehabilitation Hospital, Department of Cardiology, Cluj-Napoca, Romania. Electronic address: pop67dana@gmail.com. 3. "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Rehabilitation Hospital, Department of Cardiology, Cluj-Napoca, Romania.
Abstract
AIM: To evaluate N-terminal pro-BNP-type natriuretic peptide (NT-proBNP) plasmatic levels in heart failure patients with/without atrial fibrillation (AFib) and with/without diabetes (DM). METHODS: The study enrolled 120 patients with heart failure, age 71.26±9.14, 48.3% AFib and 30.8% with DM. The patients were divided into 4 groups according to the presence or absence of AFib and DM: group 1, 46 patients in sinus rhythm (SR) without DM; group 2, 16 patients in SR with DM; group 3, 37 patients with AFib and without DM; group 4, 21 patients with both AFib and DM. RESULTS: The patients in SR with DM displayed lower NT-proBNP levels than those with AFib without DM (1196.75±1183.11 vs 1940.59±963.665, p=0.02). We recorded no significant difference in comparison with the patients who had both AFib and DM (1196.75±1183.11 vs 1452.67±1257.94, p=NS). There was no significant difference between groups 3 and 4. Statistically significant correlations between ejection fraction, namely NYHA class and NT-proBNP levels were recorded only in the patients in SR-group 1 (r=-0.42, p<0.01) and group 2 (r=-0.66, p<0.01). CONCLUSIONS: Correlations between plasma NT-proBNP levels and ejection fraction, namely NYHA class, were evinced only in patients in SR.
AIM: To evaluate N-terminal pro-BNP-type natriuretic peptide (NT-proBNP) plasmatic levels in heart failurepatients with/without atrial fibrillation (AFib) and with/without diabetes (DM). METHODS: The study enrolled 120 patients with heart failure, age 71.26±9.14, 48.3% AFib and 30.8% with DM. The patients were divided into 4 groups according to the presence or absence of AFib and DM: group 1, 46 patients in sinus rhythm (SR) without DM; group 2, 16 patients in SR with DM; group 3, 37 patients with AFib and without DM; group 4, 21 patients with both AFib and DM. RESULTS: The patients in SR with DM displayed lower NT-proBNP levels than those with AFib without DM (1196.75±1183.11 vs 1940.59±963.665, p=0.02). We recorded no significant difference in comparison with the patients who had both AFib and DM (1196.75±1183.11 vs 1452.67±1257.94, p=NS). There was no significant difference between groups 3 and 4. Statistically significant correlations between ejection fraction, namely NYHA class and NT-proBNP levels were recorded only in the patients in SR-group 1 (r=-0.42, p<0.01) and group 2 (r=-0.66, p<0.01). CONCLUSIONS: Correlations between plasma NT-proBNP levels and ejection fraction, namely NYHA class, were evinced only in patients in SR.
Authors: F I Fringu; A V Sitar-Taut; B Caloian; D Zdrenghea; D Comsa; G Gusetu; D Pop Journal: Acta Endocrinol (Buchar) Date: 2020 Apr-Jun Impact factor: 0.877