Saeed Alshahrani1, Abdullatif Khan2. 1. College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. 2. Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Abstract
BACKGROUND: Lingual ASPS is extremely rare and aggressive tumor. rearrangement is typically detected in ASPS patients using FISH analysis. AIM: To present the clinical, histopathological, and radiological features of lingual Alveolar Soft Part Sarcoma. METHOD: A 30-year-old male presented with a painless, slowly growing mass of the tongue. Initial impression was of benign vascular lesion. Later, the patient became symptomatic as the mass progressed in size, which necessitated further investigations. RESULT: A lip-split, mandibulotomy was performed for the excision of the tumor and revealed an alveolar soft part sarcoma with PAS-positive, diastase resistant intracytoplasmic granules. However, molecular analysis using FISH was negative for TFE3 rearrangement. Patient underwent partial glossectomy with postoperative radiotherapy. CONCLUSION: Clinical and pathological correlation of ASPS is very useful to reach a proper diagnosis.
BACKGROUND: Lingual ASPS is extremely rare and aggressive tumor. rearrangement is typically detected in ASPSpatients using FISH analysis. AIM: To present the clinical, histopathological, and radiological features of lingual Alveolar Soft Part Sarcoma. METHOD: A 30-year-old male presented with a painless, slowly growing mass of the tongue. Initial impression was of benign vascular lesion. Later, the patient became symptomatic as the mass progressed in size, which necessitated further investigations. RESULT: A lip-split, mandibulotomy was performed for the excision of the tumor and revealed an alveolar soft part sarcoma with PAS-positive, diastase resistant intracytoplasmic granules. However, molecular analysis using FISH was negative for TFE3 rearrangement. Patient underwent partial glossectomy with postoperative radiotherapy. CONCLUSION: Clinical and pathological correlation of ASPS is very useful to reach a proper diagnosis.
Authors: Prokopios P Argyris; Robyn C Reed; J Carlos Manivel; Dolores Lopez-Terrada; Jared Jakacky; Zuzan Cayci; Konstantinos I Tosios; Stefan E Pambuccian; Lester D R Thompson; Ioannis G Koutlas Journal: Head Neck Pathol Date: 2012-09-08