Teresa T Fung1, Ellen A Struijk2,3, Fernando Rodriguez-Artalejo2,3,4, Walter C Willett5,6, Esther Lopez-Garcia2,3,4. 1. Department of Nutrition, Simmons University, Boston, MA, USA. 2. Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-Idi Paz, Madrid, Spain. 3. CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain. 4. Instituto Madrileño De Estudios Avanzado-Food Institute, Campus de Excelencia Internacional Universidad Autónoma de Madrid+Centro Superior de Investigaciones Científicas, Madrid, Spain. 5. Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA. 6. Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Abstract
BACKGROUND: Prior research has suggested that the antioxidative and anti-inflammatory potential of fruits and vegetables may ameliorate aging-related frailty. OBJECTIVE: We sought to prospectively examine the association between fruit and vegetable intake and incident frailty in older women. DESIGN: We followed 78,366 nonfrail women aged ≥60 y from the Nurses' Health Study from 1990 to 2014. In this analysis, the primary exposure was the intake of total fruits and vegetables, assessed with an FFQ administered 6 times during follow-up. Frailty was defined as having ≥3 of the following 5 criteria from the FRAIL scale: fatigue, poor strength, low aerobic capacity, having ≥5 illnesses, and ≥5% weight loss. Cox models adjusted for potential confounders were used to estimate HRs and 95% CIs for the association between fruit and vegetable intake and incident frailty. RESULTS: In total, 12,434 (15.9%) incident frailty cases were accrued during follow-up. Total fruit and vegetable intakes were associated with a lower risk of frailty (adjusted HR comparing 7+ servings/d compared with <3 servings/d: 0.92; 95% CI: 0.85, 0.99). The inverse association appeared to be stronger for those with physical activity above the median (P-interaction < 0.05). Among physically active women, compared with those who consumed <3 servings/d, the HR for 7+ servings/d was 0.68 (95% CI: 0.57, 0.81). CONCLUSION: Higher fruit and vegetable intake was associated with a lower risk of frailty in this cohort of US women aged ≥60 y. Because of limited evidence on intakes of fruits and vegetables and the development of frailty, more data are needed to confirm our results.
BACKGROUND: Prior research has suggested that the antioxidative and anti-inflammatory potential of fruits and vegetables may ameliorate aging-related frailty. OBJECTIVE: We sought to prospectively examine the association between fruit and vegetable intake and incident frailty in older women. DESIGN: We followed 78,366 nonfrail women aged ≥60 y from the Nurses' Health Study from 1990 to 2014. In this analysis, the primary exposure was the intake of total fruits and vegetables, assessed with an FFQ administered 6 times during follow-up. Frailty was defined as having ≥3 of the following 5 criteria from the FRAIL scale: fatigue, poor strength, low aerobic capacity, having ≥5 illnesses, and ≥5% weight loss. Cox models adjusted for potential confounders were used to estimate HRs and 95% CIs for the association between fruit and vegetable intake and incident frailty. RESULTS: In total, 12,434 (15.9%) incident frailty cases were accrued during follow-up. Total fruit and vegetable intakes were associated with a lower risk of frailty (adjusted HR comparing 7+ servings/d compared with <3 servings/d: 0.92; 95% CI: 0.85, 0.99). The inverse association appeared to be stronger for those with physical activity above the median (P-interaction < 0.05). Among physically active women, compared with those who consumed <3 servings/d, the HR for 7+ servings/d was 0.68 (95% CI: 0.57, 0.81). CONCLUSION: Higher fruit and vegetable intake was associated with a lower risk of frailty in this cohort of US women aged ≥60 y. Because of limited evidence on intakes of fruits and vegetables and the development of frailty, more data are needed to confirm our results.
Authors: Mercedes Sotos-Prieto; Ellen A Struijk; Teresa T Fung; Eric B Rimm; Fernando Rodriguez-Artalejo; Walter C Willett; Frank B Hu; Esther Lopez-Garcia Journal: Age Ageing Date: 2022-02-02 Impact factor: 10.668
Authors: Mary Ni Lochlainn; Natalie J Cox; Thomas Wilson; Richard P G Hayhoe; Sheena E Ramsay; Antoneta Granic; Masoud Isanejad; Helen C Roberts; Daisy Wilson; Carly Welch; Christopher Hurst; Janice L Atkins; Nuno Mendonça; Katy Horner; Esme R Tuttiett; Yvie Morgan; Phil Heslop; Elizabeth A Williams; Claire J Steves; Carolyn Greig; John Draper; Clare A Corish; Ailsa Welch; Miles D Witham; Avan A Sayer; Sian Robinson Journal: Nutrients Date: 2021-07-09 Impact factor: 5.717