Literature DB >> 3302112

Aggravation of Parkinson's disease by cinnarizine.

J F Martí Massó, J A Obeso, N Carrera, J M Martínez-Lage.   

Abstract

The effect of cinnarizine on motor function in Parkinson's disease was evaluated in a randomised double-blind parallel study of 20 patients. Both groups were comparable in age, duration of the disease, dose of levodopa and degree of disability. A significant worsening of mobility was observed in patients treated with cinnarizine (75 mg bd), whilst no change was recorded in patients receiving placebo. Cinnarizine should be added to the list of drugs capable of aggravating Parkinson's disease.

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Year:  1987        PMID: 3302112      PMCID: PMC1032094          DOI: 10.1136/jnnp.50.6.804

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  4 in total

1.  Dihydropyridines and parkinsonism.

Authors:  J Traber; F Hoffmeister; J Kuhlmann
Journal:  Lancet       Date:  1986-08-02       Impact factor: 79.321

2.  [Parkinsonism possibly caused by cinnarizine].

Authors:  J F Martí Massó; N Carrera; E de la Puente
Journal:  Med Clin (Barc)       Date:  1985-11-09       Impact factor: 1.725

3.  Parkinsonism, tardive dyskinesia, akathisia, and depression induced by flunarizine.

Authors:  C Chouza; A Scaramelli; J L Caamaño; O De Medina; R Aljanati; S Romero
Journal:  Lancet       Date:  1986-06-07       Impact factor: 79.321

4.  In vivo effects of the Ca2+-antagonist nimodipine on dopamine metabolism in mouse brain.

Authors:  E Pileblad; A Carlsson
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

  4 in total
  5 in total

Review 1.  Do calcium antagonists have a place in the treatment of mood disorders?

Authors:  C Höschl
Journal:  Drugs       Date:  1991-11       Impact factor: 9.546

2.  Aggravation of Parkinson's disease by cinnarizine.

Authors:  M Fernandez Pardal; J Fernandez Pardal; F Micheli
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-01       Impact factor: 10.154

3.  Risk of parkinsonism induced by flunarizine or cinnarizine: a population-based study.

Authors:  Hsiu-Li Lin; Hsiu-Chen Lin; Yuan-Fu Tseng; Shih-Chang Chen; Chien-Yeh Hsu
Journal:  Eur J Clin Pharmacol       Date:  2016-12-16       Impact factor: 2.953

4.  Dopaminergic function in rat brain after oral administration of calcium-channel blockers or haloperidol. A microdialysis study.

Authors:  J Reiriz; S Ambrosio; A Cobos; M Ballarín; E Tolosa; N Mahy
Journal:  J Neural Transm Gen Sect       Date:  1994

Review 5.  Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water soluble drug with absorption window in stomach.

Authors:  Smita Raghuvanshi; Kamla Pathak
Journal:  J Drug Deliv       Date:  2014-11-13
  5 in total

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