| Literature DB >> 33020604 |
Ritchie Chen1, Felicity Gore1, Quynh-Anh Nguyen2, Charu Ramakrishnan1, Sneha Patel1, Soo Hyun Kim1, Misha Raffiee1, Yoon Seok Kim1, Brian Hsueh1, Esther Krook-Magnusson3, Ivan Soltesz2, Karl Deisseroth4,5,6.
Abstract
Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision. Using systemic viral delivery of ChRmine, we demonstrate behavioral modulation without surgery, enabling implant-free deep brain optogenetics.Entities:
Mesh：
Year: 2020 PMID： 33020604 PMCID： PMC7878426 DOI： 10.1038/s41587-020-0679-9
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908