Literature DB >> 33017208

Progress Toward Cardiac Xenotransplantation.

Richard N Pierson1,2, Jay A Fishman2, Gregory D Lewis3, David A D'Alessandro1, Margaret R Connolly1,2, Lars Burdorf1,2, Joren C Madsen1,2, Agnes M Azimzadeh1,2.   

Abstract

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.

Entities:  

Keywords:  cardiomyopathies; genetic engineering; heart failure; heart transplantation; heterografts; myocardial ischemia; transplantation, heterologous

Mesh：

Year:  2020        PMID： 33017208      PMCID： PMC7990044          DOI： 10.1161/CIRCULATIONAHA.120.048186

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


  54 in total

1.  Uncertainty in xenotransplantation: individual benefit versus collective risk.

Authors:  F H Bach; J A Fishman; N Daniels; J Proimos; B Anderson; C B Carpenter; L Forrow; S C Robson; H V Fineberg
Journal:  Nat Med       Date:  1998-02       Impact factor: 53.440

2.  Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.

Authors:  Gang Chen; Hua Qian; Thomas Starzl; Hongtao Sun; Bertha Garcia; Ximo Wang; Yishai Wise; Yuanqing Liu; Ying Xiang; Laura Copeman; Weihua Liu; Anthony Jevnikar; William Wall; David K C Cooper; Noriko Murase; Yifan Dai; Wanyu Wang; Yuliang Xiong; David J White; Robert Zhong
Journal:  Nat Med       Date:  2005-11-27       Impact factor: 53.440

3.  Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts.

Authors:  Hayato Iwase; Hidetaka Hara; Mohamed Ezzelarab; Tao Li; Zhongqiang Zhang; Bingsi Gao; Hong Liu; Cassandra Long; Yi Wang; Amy Cassano; Edwin Klein; Carol Phelps; David Ayares; Abhinav Humar; Martin Wijkstrom; David K C Cooper
Journal:  Xenotransplantation       Date:  2017-03-17       Impact factor: 3.907

4.  A prospective randomized trial of pretransfusion/azathioprine/prednisone versus cyclosporine/prednisone immunosuppression in cardiac transplant recipients: preliminary results.

Authors:  G R Barnhart; A Hastillo; M H Goldman; S Szentpetery; T C Wolfgang; T Mohanakumar; M R Katz; S Rider; J Hanrahan; R R Lower
Journal:  Circulation       Date:  1985-09       Impact factor: 29.690

5.  Prevention of hyperacute rejection by human decay accelerating factor in xenogeneic perfused working hearts.

Authors:  M Schmoeckel; G Nollert; M Shahmohammadi; V K Young; G Chavez; W Kasper-König; D J White; J Müller-Höcker; R M Arendt; U Wilbert-Lampen; C Hammer; B Reichart
Journal:  Transplantation       Date:  1996-09-27       Impact factor: 4.939

Review 6.  Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation.

Authors:  Peter J Cowan; Simon C Robson
Journal:  Int J Surg       Date:  2015-07-26       Impact factor: 6.071

7.  Production of alpha 1,3-galactosyltransferase-deficient pigs.

Authors:  Carol J Phelps; Chihiro Koike; Todd D Vaught; Jeremy Boone; Kevin D Wells; Shu-Hung Chen; Suyapa Ball; Susan M Specht; Irina A Polejaeva; Jeff A Monahan; Pete M Jobst; Sugandha B Sharma; Ashley E Lamborn; Amy S Garst; Marilyn Moore; Anthony J Demetris; William A Rudert; Rita Bottino; Suzanne Bertera; Massimo Trucco; Thomas E Starzl; Yifan Dai; David L Ayares
Journal:  Science       Date:  2002-12-19       Impact factor: 47.728

8.  Prevalence and significance of arrhythmias in long-term survivors of cardiac transplantation.

Authors:  D W Romhilt; M Doyle; K B Sagar; A Hastillo; T C Wolfgang; R R Lower; M L Hess
Journal:  Circulation       Date:  1982-08       Impact factor: 29.690

9.  Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival.

Authors:  Andrew B Adams; Steven C Kim; Gregory R Martens; Joseph M Ladowski; Jose L Estrada; Luz M Reyes; Cindy Breeden; Allison Stephenson; Devin E Eckhoff; Matt Tector; Alfred Joseph Tector
Journal:  Ann Surg       Date:  2018-10       Impact factor: 12.969

10.  Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

Authors:  D K Cooper; A H Good; E Koren; R Oriol; A J Malcolm; R M Ippolito; F A Neethling; Y Ye; E Romano; N Zuhdi
Journal:  Transpl Immunol       Date:  1993       Impact factor: 1.708
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  5 in total

Review 1.  Xenotransplantation: A New Era.

Authors:  Amber N Carrier; Anjali Verma; Muhammad Mohiuddin; Manuel Pascual; Yannick D Muller; Alban Longchamp; Chandra Bhati; Leo H Buhler; Daniel G Maluf; Raphael P H Meier
Journal:  Front Immunol       Date:  2022-06-09       Impact factor: 8.786

Review 2.  Signaling cascades in the failing heart and emerging therapeutic strategies.

Authors:  Xin He; Tailai Du; Tianxin Long; Xinxue Liao; Yugang Dong; Zhan-Peng Huang
Journal:  Signal Transduct Target Ther       Date:  2022-04-23

3.  Cardiac Xenotransplantation: 5 Things Every Cardiologist Should Know.

Authors:  Bin Q Yang; Arick C Park; Joel D Schilling
Journal:  JACC Basic Transl Sci       Date:  2022-03-30

4.  The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors.

Authors:  Corbin E Goerlich; Bartley Griffith; Peter Hanna; Susie N Hong; David Ayares; Avneesh K Singh; Muhammad M Mohiuddin
Journal:  J Thorac Cardiovasc Surg       Date:  2021-09-04       Impact factor: 5.209

Review 5.  Aspects of the Complement System in New Era of Xenotransplantation.

Authors:  Shuji Miyagawa; Akira Maeda; Chiyoshi Toyama; Shuhei Kogata; Chizu Okamatsu; Riho Yamamoto; Kazunori Masahata; Masafumi Kamiyama; Hiroshi Eguchi; Masahito Watanabe; Hiroshi Nagashima; Masahito Ikawa; Katsuyoshi Matsunami; Hiroomi Okuyama
Journal:  Front Immunol       Date:  2022-04-14       Impact factor: 8.786
  5 in total

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