Ashlee R Loughan1,2,3, Farah J Aslanzadeh4, Julia Brechbiel4, Gary Rodin5,6, Mariya Husain3, Sarah E Braun4,7, Kelcie D Willis4, Autumn Lanoye8. 1. Virginia Commonwealth University, Department of Neurology, Division of Neuro-Oncology, Richmond, Virginia. 2. Massey Cancer Center, Richmond, Virginia. 3. Virginia Commonwealth University, School of Medicine, Richmond, Virginia. 4. Virginia Commonwealth University, Department of Psychology, Richmond, Virginia. 5. Princess Margaret Cancer Centre, University Health Network, Department of Supportive Care, Toronto, Ontario, Canada. 6. University of Toronto, Department of Psychiatry, Toronto, Ontario, Canada. 7. Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, Charleston, South Carolina. 8. Virginia Commonwealth University, School of Medicine Department of Health Behavior and Policy, Richmond, Virginia.
Abstract
BACKGROUND: A diagnosis of cancer may increase mortality salience and provoke death-related distress. Primary brain tumor (PBT) patients may be at particular risk for such distress given the certainty of tumor progression, lack of curative treatments, and poor survival rates. This study is the first to examine the prevalence of death-related distress and its correlates in PBT patients. METHODS: Adult PBT patients (N = 105) enrolled in this cross-sectional study and completed the Death Distress Scale (subscales: Death Depression, Death Anxiety, Death Obsession), Generalized Anxiety Disorder-7, and Patient Health Questionnaire-9. Prevalence and predictors of death-related distress, and the relationships of demographic variables to clusters of distress, were explored. RESULTS: The majority of PBT patients endorsed clinically significant death-related distress in at least one domain. Death anxiety was endorsed by 81%, death depression by 12.5%, and death obsession by 10.5%. Generalized anxiety was the only factor associated with global death-related distress. Cluster analysis yielded 4 profiles: global distress, emotional distress, resilience, and existential distress. Participants in the resilience cluster were significantly further out from diagnosis than those in the existential distress cluster. There were no differences in cluster membership based on age, sex, or tumor grade. CONCLUSIONS: PBT patients appear to have a high prevalence of death-related distress, particularly death anxiety. Further, 4 distinct profiles of distress were identified, supporting the need for tailored approaches to addressing death-related distress. A shift in clusters of distress based on time since diagnosis also suggest the need for future longitudinal assessment.
BACKGROUND: A diagnosis of cancer may increase mortality salience and provoke death-related distress. Primary brain tumor (PBT) patients may be at particular risk for such distress given the certainty of tumor progression, lack of curative treatments, and poor survival rates. This study is the first to examine the prevalence of death-related distress and its correlates in PBT patients. METHODS: Adult PBT patients (N = 105) enrolled in this cross-sectional study and completed the Death Distress Scale (subscales: Death Depression, Death Anxiety, Death Obsession), Generalized Anxiety Disorder-7, and Patient Health Questionnaire-9. Prevalence and predictors of death-related distress, and the relationships of demographic variables to clusters of distress, were explored. RESULTS: The majority of PBT patients endorsed clinically significant death-related distress in at least one domain. Death anxiety was endorsed by 81%, death depression by 12.5%, and death obsession by 10.5%. Generalized anxiety was the only factor associated with global death-related distress. Cluster analysis yielded 4 profiles: global distress, emotional distress, resilience, and existential distress. Participants in the resilience cluster were significantly further out from diagnosis than those in the existential distress cluster. There were no differences in cluster membership based on age, sex, or tumor grade. CONCLUSIONS: PBT patients appear to have a high prevalence of death-related distress, particularly death anxiety. Further, 4 distinct profiles of distress were identified, supporting the need for tailored approaches to addressing death-related distress. A shift in clusters of distress based on time since diagnosis also suggest the need for future longitudinal assessment.
Authors: Parvez Thekkumpurath; Jane Walker; Isabella Butcher; Laura Hodges; Annet Kleiboer; Mark O'Connor; Lucy Wall; Gordon Murray; Kurt Kroenke; Michael Sharpe Journal: Cancer Date: 2010-08-24 Impact factor: 6.860
Authors: Barbara L Andersen; Robert J DeRubeis; Barry S Berman; Jessie Gruman; Victoria L Champion; Mary Jane Massie; Jimmie C Holland; Ann H Partridge; Kate Bak; Mark R Somerfield; Julia H Rowland Journal: J Clin Oncol Date: 2014-04-14 Impact factor: 44.544
Authors: Ashlee R Loughan; Kelcie D Willis; Sarah Ellen Braun; Gary Rodin; Autumn Lanoye; Alexandria E Davies; Dace Svikis; Suzanne Mazzeo; Mark Malkin; Leroy Thacker Journal: J Neurooncol Date: 2022-04-18 Impact factor: 4.506
Authors: Kathleen Van Dyk; Lucy Wall; Brandon F Heimberg; Justin Choi; Catalina Raymond; Chencai Wang; Albert Lai; Timothy F Cloughesy; Benjamin M Ellingson; Phioanh Nghiemphu Journal: CNS Oncol Date: 2022-05-18