Literature DB >> 33006377

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder.

Thomas van Doeveren1, Jose A Nakauma-Gonzalez1,2,3, Andrew S Mason4,5, Geert J L H van Leenders6, Tahlita C M Zuiverloon1, Ellen C Zwarthoff6, Isabelle C Meijssen6, Angelique C van der Made6, Antoine G van der Heijden7, Kees Hendricksen8, Bas W G van Rhijn8,9, Charlotte S Voskuilen8, Job van Riet1,3, Winand N M Dinjens6, Hendrikus J Dubbink6, Harmen J G van de Werken1,3, Joost L Boormans1.   

Abstract

The risk of developing urothelial carcinoma of the bladder (UCB) in patients treated by radical nephroureterectomy (RNU) for an upper urinary tract urothelial carcinoma (UTUC) is 22% to 47% in the 2 years after surgery. Subject of debate remains whether UTUC and the subsequent UCB are clonally related or represent separate origins. To investigate the clonal relationship between both entities, we performed targeted DNA sequencing of a panel of 41 genes on matched normal and tumor tissue of 15 primary UTUC patients treated by RNU who later developed 19 UCBs. Based on the detected tumor-specific DNA aberrations, the paired UTUC and UCB(s) of 11 patients (73.3%) showed a clonal relation, whereas in four patients the molecular results did not indicate a clear clonal relationship. Our results support the hypothesis that UCBs following a primary surgically resected UTUC are predominantly clonally derived recurrences and not separate entities.
© 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.

Entities:  

Keywords:  bladder carcinoma; clonality; upper urinary tract carcinoma; urothelial carcinoma

Mesh：

Year:  2020        PMID： 33006377      PMCID： PMC7821318          DOI： 10.1002/ijc.33327

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  17 in total

1.  Mutagenic Factors and Complex Clonal Relationship of Multifocal Urothelial Cell Carcinoma.

Authors:  Yiqing Du; Ruoyan Li; Zhanghua Chen; Xiaofeng Wang; Tao Xu; Fan Bai
Journal:  Eur Urol       Date:  2016-10-12       Impact factor: 20.096

2.  Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

Authors:  Yves Allory; Willemien Beukers; Ana Sagrera; Marta Flández; Miriam Marqués; Mirari Márquez; Kirstin A van der Keur; Lars Dyrskjot; Irene Lurkin; Marcel Vermeij; Alfredo Carrato; Josep Lloreta; José A Lorente; Enrique Carrillo-de Santa Pau; Roy G Masius; Manolis Kogevinas; Ewout W Steyerberg; Angela A G van Tilborg; Cheno Abas; Torben F Orntoft; Tahlita C M Zuiverloon; Núria Malats; Ellen C Zwarthoff; Francisco X Real
Journal:  Eur Urol       Date:  2013-09-07       Impact factor: 20.096

3.  Reliable detection of subclonal single-nucleotide variants in tumour cell populations.

Authors:  Moritz Gerstung; Christian Beisel; Markus Rechsteiner; Peter Wild; Peter Schraml; Holger Moch; Niko Beerenwinkel
Journal:  Nat Commun       Date:  2012-05-01       Impact factor: 14.919

4.  Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma.

Authors:  François Audenet; Sumit Isharwal; Eugene K Cha; Mark T A Donoghue; Esther N Drill; Irina Ostrovnaya; Eugene J Pietzak; John P Sfakianos; Aditya Bagrodia; Paari Murugan; Guido Dalbagni; Timothy F Donahue; Jonathan E Rosenberg; Dean F Bajorin; Maria E Arcila; Jaclyn F Hechtman; Michael F Berger; Barry S Taylor; Hikmat Al-Ahmadie; Gopa Iyer; Bernard H Bochner; Jonathan A Coleman; David B Solit
Journal:  Clin Cancer Res       Date:  2018-10-23       Impact factor: 12.531

5.  Diagnostic Detection of Allelic Losses and Imbalances by Next-Generation Sequencing: 1p/19q Co-Deletion Analysis of Gliomas.

Authors:  Hendrikus J Dubbink; Peggy N Atmodimedjo; Ronald van Marion; Niels M G Krol; Peter H J Riegman; Johan M Kros; Martin J van den Bent; Winand N M Dinjens
Journal:  J Mol Diagn       Date:  2016-07-25       Impact factor: 5.568

6.  USING SOMATIC MUTATION DATA TO TEST TUMORS FOR CLONAL RELATEDNESS.

Authors:  Irina Ostrovnaya; Venkatraman E Seshan; Colin B Begg
Journal:  Ann Appl Stat       Date:  2015-11-02       Impact factor: 2.083

7.  Molecular determination of the clonal relationships between multiple tumors in BRCA1/2-associated breast and/or ovarian cancer patients is clinically relevant.

Authors:  Willemina R R Geurts-Giele; Victorien M T van Verschuer; Carolien H M van Deurzen; Paul J van Diest; Rute M S M Pedrosa; J Margriet Collée; Linetta B Koppert; Caroline Seynaeve; Winand N M Dinjens
Journal:  Mod Pathol       Date:  2016-09-09       Impact factor: 7.842

8.  Highly accurate DNA-based detection and treatment results of MET exon 14 skipping mutations in lung cancer.

Authors:  M A Pruis; W R R Geurts-Giele; Thüsen J H von der; I C Meijssen; W N M Dinjens; J G J V Aerts; A M C Dingemans; M P Lolkema; M S Paats; H J Dubbink
Journal:  Lung Cancer       Date:  2019-11-18       Impact factor: 5.705

9.  Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification.

Authors:  Mieke R Van Bockstal; Marie Colombe Agahozo; Ronald van Marion; Peggy N Atmodimedjo; Hein F B M Sleddens; Winand N M Dinjens; Lindy L Visser; Esther H Lips; Jelle Wesseling; Carolien H M van Deurzen
Journal:  Mol Oncol       Date:  2020-03-05       Impact factor: 6.603

10.  The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder.

Authors:  Thomas van Doeveren; Jose A Nakauma-Gonzalez; Andrew S Mason; Geert J L H van Leenders; Tahlita C M Zuiverloon; Ellen C Zwarthoff; Isabelle C Meijssen; Angelique C van der Made; Antoine G van der Heijden; Kees Hendricksen; Bas W G van Rhijn; Charlotte S Voskuilen; Job van Riet; Winand N M Dinjens; Hendrikus J Dubbink; Harmen J G van de Werken; Joost L Boormans
Journal:  Int J Cancer       Date:  2020-10-13       Impact factor: 7.396
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  4 in total

1.  Factors Predicting Oncological Outcomes of Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma in Taiwan.

Authors:  I-Hsuan Alan Chen; Chao-Hsiang Chang; Chi-Ping Huang; Wen-Jeng Wu; Ching-Chia Li; Chung-Hsin Chen; Chao-Yuan Huang; Chi-Wen Lo; Chih-Chin Yu; Chung-You Tsai; Wei-Che Wu; Jen-Shu Tseng; Wun-Rong Lin; Yuan-Hong Jiang; Yu-Khun Lee; Yeong-Chin Jou; Ian-Seng Cheong; Thomas Y Hsueh; Allen W Chiu; Yung-Tai Chen; Jih-Sheng Chen; Bing-Juin Chiang; Yao-Chou Tsai; Wei Yu Lin; Chia-Chang Wu; Jen-Tai Lin; Chia-Cheng Yu
Journal:  Front Oncol       Date:  2022-01-13       Impact factor: 6.244

2.  Predictive Value of Preoperative Positive Urine Cytology for Development of Bladder Cancer After Nephroureterectomy in Patients With Upper Urinary Tract Urothelial Carcinoma: A Prognostic Nomogram Based on a Retrospective Multicenter Cohort Study and Systematic Meta-Analysis.

Authors:  Bo Fan; Yuanbin Huang; Shuang Wen; Qiliang Teng; Xinrui Yang; Man Sun; Tingyu Chen; Yan Huang; Yumei Wang; Zhiyu Liu
Journal:  Front Oncol       Date:  2021-10-01       Impact factor: 6.244

3.  Development of secondary urothelial carcinoma following complete response to immune checkpoint inhibitors.

Authors:  Jean-Michel Lavoie; Gillian Vandekerkhove; Andrew J Murtha; Gang Wang; Alexander W Wyatt; Bernhard J Eigl
Journal:  Urol Case Rep       Date:  2021-06-25

4.  The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder.

Authors:  Thomas van Doeveren; Jose A Nakauma-Gonzalez; Andrew S Mason; Geert J L H van Leenders; Tahlita C M Zuiverloon; Ellen C Zwarthoff; Isabelle C Meijssen; Angelique C van der Made; Antoine G van der Heijden; Kees Hendricksen; Bas W G van Rhijn; Charlotte S Voskuilen; Job van Riet; Winand N M Dinjens; Hendrikus J Dubbink; Harmen J G van de Werken; Joost L Boormans
Journal:  Int J Cancer       Date:  2020-10-13       Impact factor: 7.396
  4 in total

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