Literature DB >> 33006345

Small molecule induced toxic human-IAPP species characterized by NMR.

Sarah J Cox1, Diana C Rodriguez Camargo, Young-Ho Lee, Romeo C A Dubini, Petra Rovó, Magdalena I Ivanova, Vediappen Padmini, Bernd Reif, Ayyalusamy Ramamoorthy.   

Abstract

In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-β1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.

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Year:  2020        PMID： 33006345      PMCID： PMC7641245          DOI： 10.1039/d0cc04803h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  25 in total

Review 1.  Inhibition of amyloid formation.

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2.  Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Authors:  Georg Meisl; Julius B Kirkegaard; Paolo Arosio; Thomas C T Michaels; Michele Vendruscolo; Christopher M Dobson; Sara Linse; Tuomas P J Knowles
Journal:  Nat Protoc       Date:  2016-01-07       Impact factor: 13.491

Review 3.  Small molecule probes of protein aggregation.

Authors:  Lydia M Young; Alison E Ashcroft; Sheena E Radford
Journal:  Curr Opin Chem Biol       Date:  2017-06-22       Impact factor: 8.822

4.  Therapeutic Potential of Small Molecule Inhibitors.

Authors:  Nimmish Khera; Sandeep Rajput
Journal:  J Cell Biochem       Date:  2017-01-10       Impact factor: 4.429

Review 5.  The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.

Authors:  I W Hamley
Journal:  Chem Rev       Date:  2012-07-19       Impact factor: 60.622

Review 6.  Insight into amyloid structure using chemical probes.

Authors:  Ashley A Reinke; Jason E Gestwicki
Journal:  Chem Biol Drug Des       Date:  2011-04-26       Impact factor: 2.817

Review 7.  What amyloid ligands can tell us about molecular polymorphism and disease.

Authors:  Harry LeVine; Lary C Walker
Journal:  Neurobiol Aging       Date:  2016-03-24       Impact factor: 4.673

8.  pH dependence of amylin fibrillization.

Authors:  Suman Jha; Jessica M Snell; Sarah R Sheftic; Sharadrao M Patil; Stephen B Daniels; Frederick W Kolling; Andrei T Alexandrescu
Journal:  Biochemistry       Date:  2014-01-08       Impact factor: 3.162

9.  High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification.

Authors:  Samuel A Kotler; Jeffrey R Brender; Subramanian Vivekanandan; Yuta Suzuki; Kazutoshi Yamamoto; Martine Monette; Janarthanan Krishnamoorthy; Patrick Walsh; Meagan Cauble; Mark M Banaszak Holl; E Neil G Marsh; Ayyalusamy Ramamoorthy
Journal:  Sci Rep       Date:  2015-07-03       Impact factor: 4.379

10.  Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry.

Authors:  Lydia M Young; Janet C Saunders; Rachel A Mahood; Charlotte H Revill; Richard J Foster; Ling-Hsien Tu; Daniel P Raleigh; Sheena E Radford; Alison E Ashcroft
Journal:  Nat Chem       Date:  2014-12-08       Impact factor: 24.427
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  2 in total

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Journal:  ACS Pharmacol Transl Sci       Date:  2021-07-21

Review 2.  Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.

Authors:  Phuong H Nguyen; Ayyalusamy Ramamoorthy; Bikash R Sahoo; Jie Zheng; Peter Faller; John E Straub; Laura Dominguez; Joan-Emma Shea; Nikolay V Dokholyan; Alfonso De Simone; Buyong Ma; Ruth Nussinov; Saeed Najafi; Son Tung Ngo; Antoine Loquet; Mara Chiricotto; Pritam Ganguly; James McCarty; Mai Suan Li; Carol Hall; Yiming Wang; Yifat Miller; Simone Melchionna; Birgit Habenstein; Stepan Timr; Jiaxing Chen; Brianna Hnath; Birgit Strodel; Rakez Kayed; Sylvain Lesné; Guanghong Wei; Fabio Sterpone; Andrew J Doig; Philippe Derreumaux
Journal:  Chem Rev       Date:  2021-02-05       Impact factor: 60.622
  2 in total

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