Chirag M Vyas1, Soshiro Ogata2,3,4, Charles F Reynolds5, David Mischoulon1, Grace Chang6, Nancy R Cook7,8, JoAnn E Manson2,7,8, Marta Crous-Bou8,9,10, Immaculata De Vivo2,8, Olivia I Okereke1,2,8. 1. Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 3. Faculty of Nursing, School of Health Science, Fujita Health University, Toyoake, Japan. 4. Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Osaka, Japan. 5. Department of Psychiatry, UPMC and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 6. Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA. 7. Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 8. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. 9. BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain. 10. Department of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Abstract
BACKGROUND: Adherence to healthy lifestyles/behaviours promotes healthy ageing. However, little is known about whether age, sex and/or race/ethnicity moderate associations of lifestyle/behavioural factors with relative telomere length (RTL), a potential biomarker of ageing. METHODS: We included 749 midlife to older non-Hispanic White (n = 254), Black (n = 248) and Hispanic (n = 247) US participants [mean (standard deviation) age = 69.3 (7.2) years; women: 50.5%]. We extracted genomic DNA from peripheral leucocytes. RTL was assayed using real-time quantitative polymerase chain reaction. Multivariable regression was used to examine associations between lifestyle/behavioural exposures (i.e. physical activity, alcohol consumption, smoking and depression) with RTL. RESULTS: Increasing chronological age was associated with shorter RTL (P < 0.01). Higher physical activity was associated with longer RTL (P-trend = 0.03); daily versus never/rare alcohol consumption and 30+ versus <5 smoking pack-year were associated with shorter RTLs (P-trend = 0.02). Associations varied significantly by sex and race/ethnicity. The association between physical activity and longer RTL appeared strongest among non-Hispanic Whites (P-interaction = 0.01). Compared to men, women had stronger associations between heavy smoking and shorter RTLs (P-interaction = 0.03). Light/moderate alcohol consumption (monthly/weekly) was associated with longer RTL among non-Hispanic Whites, while daily consumption was related to shorter RTLs among Blacks and Hispanics (P-interactions < 0.01). Associations of daily alcohol and heavy smoking with shorter RTLs were particularly apparent among Black women. CONCLUSION: We observed novel variations by sex and race/ethnicity in associations between lifestyle/behavioural factors and RTL. Further work is needed to replicate these findings and to address potential public health implications for modifying strategies by sex or across racial/ethnic groups to optimise lifestyles/behaviours for healthy ageing. Published by Oxford University Press on behalf of the British Geriatrics Society 2020.
BACKGROUND: Adherence to healthy lifestyles/behaviours promotes healthy ageing. However, little is known about whether age, sex and/or race/ethnicity moderate associations of lifestyle/behavioural factors with relative telomere length (RTL), a potential biomarker of ageing. METHODS: We included 749 midlife to older non-Hispanic White (n = 254), Black (n = 248) and Hispanic (n = 247) US participants [mean (standard deviation) age = 69.3 (7.2) years; women: 50.5%]. We extracted genomic DNA from peripheral leucocytes. RTL was assayed using real-time quantitative polymerase chain reaction. Multivariable regression was used to examine associations between lifestyle/behavioural exposures (i.e. physical activity, alcohol consumption, smoking and depression) with RTL. RESULTS: Increasing chronological age was associated with shorter RTL (P < 0.01). Higher physical activity was associated with longer RTL (P-trend = 0.03); daily versus never/rare alcohol consumption and 30+ versus <5 smoking pack-year were associated with shorter RTLs (P-trend = 0.02). Associations varied significantly by sex and race/ethnicity. The association between physical activity and longer RTL appeared strongest among non-Hispanic Whites (P-interaction = 0.01). Compared to men, women had stronger associations between heavy smoking and shorter RTLs (P-interaction = 0.03). Light/moderate alcohol consumption (monthly/weekly) was associated with longer RTL among non-Hispanic Whites, while daily consumption was related to shorter RTLs among Blacks and Hispanics (P-interactions < 0.01). Associations of daily alcohol and heavy smoking with shorter RTLs were particularly apparent among Black women. CONCLUSION: We observed novel variations by sex and race/ethnicity in associations between lifestyle/behavioural factors and RTL. Further work is needed to replicate these findings and to address potential public health implications for modifying strategies by sex or across racial/ethnic groups to optimise lifestyles/behaviours for healthy ageing. Published by Oxford University Press on behalf of the British Geriatrics Society 2020.
Entities:
Keywords:
telomere length; biomarker; health disparities; older people; race/ethnicity
Authors: Mengmeng Du; Jennifer Prescott; Peter Kraft; Jiali Han; Edward Giovannucci; Susan E Hankinson; Immaculata De Vivo Journal: Am J Epidemiol Date: 2012-02-01 Impact factor: 4.897
Authors: Roxanne Schaakxs; Josine E Verhoeven; Richard C Oude Voshaar; Hannie C Comijs; Brenda W J H Penninx Journal: Am J Geriatr Psychiatry Date: 2014-06-19 Impact factor: 4.105
Authors: Barbara E Ainsworth; William L Haskell; Stephen D Herrmann; Nathanael Meckes; David R Bassett; Catrine Tudor-Locke; Jennifer L Greer; Jesse Vezina; Melicia C Whitt-Glover; Arthur S Leon Journal: Med Sci Sports Exerc Date: 2011-08 Impact factor: 5.411
Authors: Olivia I Okereke; Charles F Reynolds; David Mischoulon; Grace Chang; Nancy R Cook; Trisha Copeland; Georgina Friedenberg; Julie E Buring; JoAnn E Manson Journal: Contemp Clin Trials Date: 2018-03-08 Impact factor: 2.226
Authors: JoAnn E Manson; Nancy R Cook; I-Min Lee; William Christen; Shari S Bassuk; Samia Mora; Heike Gibson; Christine M Albert; David Gordon; Trisha Copeland; Denise D'Agostino; Georgina Friedenberg; Claire Ridge; Vadim Bubes; Edward L Giovannucci; Walter C Willett; Julie E Buring Journal: N Engl J Med Date: 2018-11-10 Impact factor: 91.245
Authors: Elissa S Epel; Sharon Stein Merkin; Richard Cawthon; Elizabeth H Blackburn; Nancy E Adler; Mark J Pletcher; Teresa E Seeman Journal: Aging (Albany NY) Date: 2008-12-04 Impact factor: 5.682
Authors: Benjamin A Rybicki; Sudha M Sadasivan; Yalei Chen; Ian Loveless; Nilesh S Gupta; Dhananjay A Chitale; Sean R Williamson; Andrew G Rundle; Deliang L Tang Journal: Cancer Epidemiol Biomarkers Prev Date: 2022-05-04 Impact factor: 4.090
Authors: Harold H Lee; Sakurako S Okuzono; Eric S Kim; Immaculata De Vivo; Laura M Raffield; LáShauntá Glover; Mario Sims; Francine Grodstein; Laura D Kubzansky Journal: Psychoneuroendocrinology Date: 2020-12-29 Impact factor: 4.905
Authors: Niclas Stensson; Björn Gerdle; Linn Rönne-Petersén; Liu L Yang; Catharina Lavebratt; Torkel Falkenberg; Bijar Ghafouri Journal: J Clin Med Date: 2022-02-26 Impact factor: 4.241