Elena Succurro1, Teresa Vanessa Fiorentino2, Sofia Miceli2, Maria Perticone2, Angela Sciacqua2, Francesco Andreozzi2, Giorgio Sesti3. 1. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy succurro@unicz.it. 2. Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy. 3. Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.
Abstract
OBJECTIVE: Most but not all studies suggest that women with type 2 diabetes have higher relative risk (RR) for cardiovascular disease (CVD) than men. More uncertainty exists on whether the RR for CVD is higher in women with prediabetes compared with men with prediabetes. RESEARCH DESIGN AND METHODS: In a cross-sectional study, in 3,540 adults with normal glucose tolerance (NGT), prediabetes, and diabetes, we compared the RR for prevalent nonfatal CVD between men and women. In a longitudinal study including 1,658 adults with NGT, prediabetes, and diabetes, we compared the RR for incidences of major adverse outcomes, including all-cause death, coronary heart disease, and cerebrovascular disease events, after 5.6 years of follow-up. RESULTS: Women with prediabetes and diabetes exhibited greater relative differences in BMI, waist circumference, blood pressure, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, hs-CRP, and white blood cell count than men with prediabetes and diabetes when compared with their NGT counterparts. We found a higher RR for prevalent CVD in women with diabetes (RR 9.29; 95% CI 4.73-18.25; P < 0.0001) than in men (RR 4.56; 95% CI 3.07-6.77; P < 0.0001), but no difference in RR for CVD was observed comparing women and men with prediabetes. In the longitudinal study, we found that women with diabetes, but not those with prediabetes, have higher RR (RR 5.25; 95% CI 3.22-8.56; P < 0.0001) of incident major adverse outcomes than their male counterparts (RR 2.72; 95% CI 1.81-4.08; P < 0.0001). CONCLUSIONS: This study suggests that women with diabetes, but not those with prediabetes, have higher RR for prevalent and incident major adverse outcomes than men.
OBJECTIVE: Most but not all studies suggest that women with type 2 diabetes have higher relative risk (RR) for cardiovascular disease (CVD) than men. More uncertainty exists on whether the RR for CVD is higher in women with prediabetes compared with men with prediabetes. RESEARCH DESIGN AND METHODS: In a cross-sectional study, in 3,540 adults with normal glucose tolerance (NGT), prediabetes, and diabetes, we compared the RR for prevalent nonfatal CVD between men and women. In a longitudinal study including 1,658 adults with NGT, prediabetes, and diabetes, we compared the RR for incidences of major adverse outcomes, including all-cause death, coronary heart disease, and cerebrovascular disease events, after 5.6 years of follow-up. RESULTS:Women with prediabetes and diabetes exhibited greater relative differences in BMI, waist circumference, blood pressure, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, hs-CRP, and white blood cell count than men with prediabetes and diabetes when compared with their NGT counterparts. We found a higher RR for prevalent CVD in women with diabetes (RR 9.29; 95% CI 4.73-18.25; P < 0.0001) than in men (RR 4.56; 95% CI 3.07-6.77; P < 0.0001), but no difference in RR for CVD was observed comparing women and men with prediabetes. In the longitudinal study, we found that women with diabetes, but not those with prediabetes, have higher RR (RR 5.25; 95% CI 3.22-8.56; P < 0.0001) of incident major adverse outcomes than their male counterparts (RR 2.72; 95% CI 1.81-4.08; P < 0.0001). CONCLUSIONS: This study suggests that women with diabetes, but not those with prediabetes, have higher RR for prevalent and incident major adverse outcomes than men.
Authors: Elena Succurro; Patrizia Vizza; Annalisa Papa; Francesco Cicone; Giuseppe Monea; Giuseppe Tradigo; Teresa Vanessa Fiorentino; Maria Perticone; Pietro Hiram Guzzi; Angela Sciacqua; Francesco Andreozzi; Pierangelo Veltri; Giuseppe Lucio Cascini; Giorgio Sesti Journal: Front Cardiovasc Med Date: 2022-06-29
Authors: Elena Succurro; Sofia Miceli; Teresa Vanessa Fiorentino; Angela Sciacqua; Maria Perticone; Francesco Andreozzi; Giorgio Sesti Journal: Cardiovasc Diabetol Date: 2021-03-06 Impact factor: 9.951
Authors: María Orosia Lucha-López; Concepción Vidal-Peracho; César Hidalgo-García; Jacobo Rodríguez-Sanz; Héctor Tricás-Vidal; Mar Hernández-Secorún; Sofía Monti-Ballano; José Miguel Tricás-Moreno; Ana Carmen Lucha-López Journal: Int J Environ Res Public Health Date: 2021-11-14 Impact factor: 3.390