Tae-Jin Song1, Jin-Woo Kim2, Jinkwon Kim3. 1. Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea. 2. Department of Oral Surgery, Ewha Womans University College of Medicine, Seoul, Korea. 3. Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Abstract
AIM: We aimed to investigate the association of periodontitis and oral hygiene indicators with changes in blood lipid parameters in a nationwide, population-based cohort in a longitudinal setting. MATERIALS AND METHODS: We included nationwide health screening program participants who underwent oral health examination in 2009-2010 and follow-up examinations for lipid profile without exposure to lipid-lowering agents. RESULTS: During the 5.19-year median follow-up, 65,078 individuals (mean age at baseline examination: 55.41 ± 7.30 years) underwent 286,218 health examinations. The prevalence of periodontitis was 39%. In the multivariate mixed model analysis, periodontitis and tooth loss were associated with decreased high-density lipoprotein cholesterol levels (β = -0.0066 mmol/L, standard error = 0.0026, p = .013) and increased triglyceride levels (β=0.0307, mmol/L, standard error = 0.0049, p < .001), respectively. Compared with tooth brushing ≤1 time/day, tooth brushing ≥3 times/day was associated with increased high-density lipoprotein cholesterol levels (β = 0.0176 mmol/L, standard error = 0.0052, p = .006) and decreased triglyceride levels (β = -0.0285 mmol/L, standard error = 0.0090, p = .001). CONCLUSIONS: Periodontitis and tooth loss may be attenuating factors for blood high-density lipoprotein cholesterol and triglyceride levels, respectively. Frequent tooth brushing may improve dyslipidaemia, particularly blood high-density lipoprotein cholesterol and triglyceride levels. Oral hygiene improvement may reduce the risk of dyslipidaemia.
AIM: We aimed to investigate the association of periodontitis and oral hygiene indicators with changes in blood lipid parameters in a nationwide, population-based cohort in a longitudinal setting. MATERIALS AND METHODS: We included nationwide health screening program participants who underwent oral health examination in 2009-2010 and follow-up examinations for lipid profile without exposure to lipid-lowering agents. RESULTS: During the 5.19-year median follow-up, 65,078 individuals (mean age at baseline examination: 55.41 ± 7.30 years) underwent 286,218 health examinations. The prevalence of periodontitis was 39%. In the multivariate mixed model analysis, periodontitis and tooth loss were associated with decreased high-density lipoprotein cholesterol levels (β = -0.0066 mmol/L, standard error = 0.0026, p = .013) and increased triglyceride levels (β=0.0307, mmol/L, standard error = 0.0049, p < .001), respectively. Compared with tooth brushing ≤1 time/day, tooth brushing ≥3 times/day was associated with increased high-density lipoprotein cholesterol levels (β = 0.0176 mmol/L, standard error = 0.0052, p = .006) and decreased triglyceride levels (β = -0.0285 mmol/L, standard error = 0.0090, p = .001). CONCLUSIONS:Periodontitis and tooth loss may be attenuating factors for blood high-density lipoprotein cholesterol and triglyceride levels, respectively. Frequent tooth brushing may improve dyslipidaemia, particularly blood high-density lipoprotein cholesterol and triglyceride levels. Oral hygiene improvement may reduce the risk of dyslipidaemia.