Laiz Laura de Godoy1,2, Cesar Augusto Pinheiro Ferreira Alves3, Juan Sebastian Martin Saavedra3, Adalberto Studart-Neto4, Ricardo Nitrini4, Claudia da Costa Leite4, Sotirios Bisdas5. 1. The National Hospital of Neurology and Neurosurgery, University College London, London, UK. laizlgodoy@gmail.com. 2. Department of Radiology and Oncology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil. laizlgodoy@gmail.com. 3. Division of Neuroradiology, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. 4. Department of Radiology and Oncology, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil. 5. The National Hospital of Neurology and Neurosurgery, University College London, London, UK.
Abstract
PURPOSE: Superagers are older adults presenting excellent memory performance that may reflect resilience to the conventional pathways of aging. Our contribution aims to shape the evidence body of the known distinctive biomarkers of superagers and their connections with the Brain and Cognitive Reserve and Brain Maintenance concepts. METHODS: We performed a systematic literature search in PubMed and ScienceDirect with no limit on publication date for studies that evaluated potential biomarkers in superagers classified by validated neuropsychological tests. Methodological quality was assessed using the QUADAS-2 tool. RESULTS: Twenty-one studies were included, the majority in neuroimaging, followed by histological, genetic, cognition, and a single one on blood plasma analysis. Superagers exhibited specific regions of cortical preservation, rather than global cortical maintenance, standing out the anterior cingulate and hippocampus regions. Both superagers and controls showed similar levels of amyloid deposition. Moreover, the functional oscillation patterns in superagers resembled those described in young adults. Most of the quality assessment for the included studies showed medium risks of bias. CONCLUSION: This systematic review supports selective cortical preservation in superagers, comprehending regions of the default mode, and salience networks, overlapped by stronger functional connectivity. In this context, the anterior cingulate cortex is highlighted as an imaging and histologic signature of these subjects. Besides, the biomarkers included pointed out that the Brain and Cognitive Reserve and Brain Maintenance concepts are independent and complementary in the superagers' setting.
PURPOSE: Superagers are older adults presenting excellent memory performance that may reflect resilience to the conventional pathways of aging. Our contribution aims to shape the evidence body of the known distinctive biomarkers of superagers and their connections with the Brain and Cognitive Reserve and Brain Maintenance concepts. METHODS: We performed a systematic literature search in PubMed and ScienceDirect with no limit on publication date for studies that evaluated potential biomarkers in superagers classified by validated neuropsychological tests. Methodological quality was assessed using the QUADAS-2 tool. RESULTS: Twenty-one studies were included, the majority in neuroimaging, followed by histological, genetic, cognition, and a single one on blood plasma analysis. Superagers exhibited specific regions of cortical preservation, rather than global cortical maintenance, standing out the anterior cingulate and hippocampus regions. Both superagers and controls showed similar levels of amyloid deposition. Moreover, the functional oscillation patterns in superagers resembled those described in young adults. Most of the quality assessment for the included studies showed medium risks of bias. CONCLUSION: This systematic review supports selective cortical preservation in superagers, comprehending regions of the default mode, and salience networks, overlapped by stronger functional connectivity. In this context, the anterior cingulate cortex is highlighted as an imaging and histologic signature of these subjects. Besides, the biomarkers included pointed out that the Brain and Cognitive Reserve and Brain Maintenance concepts are independent and complementary in the superagers' setting.
Authors: Stephanie L Harrison; Ayesha Sajjad; Wichor M Bramer; M Arfan Ikram; Henning Tiemeier; Blossom C M Stephan Journal: J Clin Exp Neuropsychol Date: 2015-03-09 Impact factor: 2.475
Authors: Sara Pudas; Jonas Persson; Maria Josefsson; Xavier de Luna; Lars-Göran Nilsson; Lars Nyberg Journal: J Neurosci Date: 2013-05-15 Impact factor: 6.167
Authors: Cristina Solé-Padullés; David Bartrés-Faz; Carme Junqué; Pere Vendrell; Lorena Rami; Imma C Clemente; Beatriu Bosch; Amparo Villar; Núria Bargalló; M Angeles Jurado; Maite Barrios; Jose Luis Molinuevo Journal: Neurobiol Aging Date: 2007-11-28 Impact factor: 4.673
Authors: L L de Godoy; A Studart-Neto; M Wylezinska-Arridge; M H Tsunemi; N C Moraes; M S Yassuda; A M Coutinho; C A Buchpiguel; R Nitrini; S Bisdas; C da Costa Leite Journal: AJNR Am J Neuroradiol Date: 2021-08-26 Impact factor: 4.966
Authors: Rowan Saloner; Judith D Lobo; Emily W Paolillo; Laura M Campbell; Scott L Letendre; Mariana Cherner; Igor Grant; Robert K Heaton; Ronald J Ellis; David J Moore Journal: J Acquir Immune Defic Syndr Date: 2022-08-01 Impact factor: 3.771
Authors: Rosaleena Mohanty; Lissett Gonzalez-Burgos; Lucio Diaz-Flores; J-Sebastian Muehlboeck; José Barroso; Daniel Ferreira; Eric Westman Journal: Front Aging Neurosci Date: 2021-07-05 Impact factor: 5.750
Authors: Rowan Saloner; Judith D Lobo; Emily W Paolillo; Laura M Campbell; Scott L Letendre; Mariana Cherner; Igor Grant; Robert K Heaton; Ronald J Ellis; Scott C Roesch; David J Moore Journal: AIDS Behav Date: 2021-12-08