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Literature DB >> 3299371

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

V K Chaudhary, D J FitzGerald, S Adhya, I Pastan.

Abstract

The transforming growth factor type alpha gene has been fused to a modified Pseudomonas toxin gene from which the cell-recognition domain has been deleted. The chimeric gene has been expressed in Escherichia coli, and the chimeric protein, PE40-TGF-alpha, has been highly purified. PE40-TGF-alpha kills cells expressing epidermal growth factor receptors and has little activity against cells with few receptors. This chimeric protein might be useful in treating cancers that contain high numbers of epidermal growth factor receptors.

Entities: Chemical

Mesh：

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Year: 1987 PMID： 3299371 PMCID： PMC305125 DOI： 10.1073/pnas.84.13.4538

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 12.779

19 in total

1. A synthetic fragment of rat transforming growth factor alpha with receptor binding and antigenic properties.

Authors: J J Nestor; S R Newman; B DeLustro; G J Todaro; A B Schreiber
Journal: Biochem Biophys Res Commun Date: 1985-05-31 Impact factor: 3.575

2. Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line.

Authors: G T Merlino; Y H Xu; N Richert; A J Clark; S Ishii; S Banks-Schlegel; I Pastan
Journal: J Clin Invest Date: 1985-03 Impact factor: 14.808

3. Rat transforming growth factor type 1: structure and relation to epidermal growth factor.

Authors: H Marquardt; M W Hunkapiller; L E Hood; G J Todaro
Journal: Science Date: 1984-03-09 Impact factor: 47.728

4. Human transforming growth factor-alpha: precursor structure and expression in E. coli.

Authors: R Derynck; A B Roberts; M E Winkler; E Y Chen; D V Goeddel
Journal: Cell Date: 1984-08 Impact factor: 41.582

5. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

Authors: A B Roberts; M A Anzano; L C Lamb; J M Smith; M B Sporn
Journal: Proc Natl Acad Sci U S A Date: 1981-09 Impact factor: 11.205

6. Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Authors: Y H Xu; N Richert; S Ito; G T Merlino; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 11.205

7. Human transforming growth factors induce tyrosine phosphorylation of EGF receptors.

Authors: F H Reynolds; G J Todaro; C Fryling; J R Stephenson
Journal: Nature Date: 1981-07-16 Impact factor: 49.962

8. Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

Authors: V S Allured; R J Collier; S F Carroll; D B McKay
Journal: Proc Natl Acad Sci U S A Date: 1986-03 Impact factor: 12.779

9. Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.

Authors: R Pirker; D J FitzGerald; T C Hamilton; R F Ozols; M C Willingham; I Pastan
Journal: Cancer Res Date: 1985-02 Impact factor: 13.312

10. Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor.

Authors: D J FitzGerald; T A Waldmann; M C Willingham; I Pastan
Journal: J Clin Invest Date: 1984-09 Impact factor: 19.456

37 in total

1. A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.

Authors: V K Chaudhary; M G Gallo; D J FitzGerald; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1990-12 Impact factor: 11.205

Review 2. Immunotoxins for targeted cancer therapy.

Authors: Robert J Kreitman
Journal: AAPS J Date: 2006-08-18 Impact factor: 4.009

3. Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines.

Authors: Joe Goldufsky; Stephen Wood; Behnam Hajihossainlou; Tooba Rehman; Omar Majdobeh; Howard L Kaufman; Carl E Ruby; Sasha H Shafikhani
Journal: J Med Microbiol Date: 2015-02 Impact factor: 2.472

4. Mutations dissociating the inhibitory activity of the pokeweed antiviral protein on eukaryote translation and Escherichia coli growth.

Authors: J M Dore; E Gras; F Depierre; J Wijdenes
Journal: Nucleic Acids Res Date: 1993-09-11 Impact factor: 16.971

Review 5. Immunotoxins: new therapeutic reagents for autoimmunity, cancer, and AIDS.

Authors: E S Vitetta
Journal: J Clin Immunol Date: 1990-11 Impact factor: 8.317

Review 6. Growth factors and oncogenes in human gastrointestinal carcinomas.

Authors: E Tahara
Journal: J Cancer Res Clin Oncol Date: 1990 Impact factor: 4.553

7. Expression of diphtheria toxin fragment A and hormone-toxin fusion proteins in toxin-resistant yeast mutants.

Authors: J P Perentesis; F S Genbauffe; S A Veldman; C L Galeotti; D M Livingston; J W Bodley; J R Murphy
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

8. Activity of a recombinant transforming growth factor-alpha-Pseudomonas exotoxin hybrid protein against primary human tumor colony-forming units.

Authors: D D Von Hoff; M H Marshall; D C Heimbrook; S M Stirdivant; J D Ahern; W K Herbert; R Z Maigetter; A Oliff
Journal: Invest New Drugs Date: 1992-04 Impact factor: 3.850

9. Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.

Authors: H Lorberboum-Galski; D FitzGerald; V Chaudhary; S Adhya; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1988-03 Impact factor: 11.205

10. Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.

Authors: U Brinkmann; L H Pai; D J FitzGerald; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1992-04-01 Impact factor: 12.779