Martin Bögemann1, Aleksandra Zagorska2, Divine Akumo3, Laila El Hadad4, Marc Pignot5. 1. Department of Urology, University of Münster, Münster, Germany, Martin.boegemann@ukmuenster.de. 2. Ipsen, Paris, France. 3. ZEG Berlin GmbH, Berlin, Germany. 4. Team Gesundheit GmbH, Essen, Germany. 5. Kantar GmbH, Munich, Germany.
Abstract
OBJECTIVES: To characterize real-world prescribing patterns and their clinical and healthcare resource utilization (HRU) implications in patients with metastatic renal cell carcinoma (mRCC) treated in Germany. METHODS: Eligible individuals were enrolled in the "Bundesverband der Betriebskrankenkassen" claims database and received targeted mRCC therapy between 1 January 2008 and 31 December 2016. Prescribing patterns and HRU were characterized by treatment line and summarized by descriptive statistics. Proxy progression-free survival (PFS) and overall survival (OS) were estimated using Kaplan-Meier curves. RESULTS: 536 patients receiving mRCC treatment were included. The median treatment duration was 4.2 months (interquartile range [IQR]: 1.7-9.3) for first-line therapy and 3.8 months (IQR: 1.7-9.1) for second-line therapy. Median PFS and OS estimates were similar for the first- and second-line treatments: PFS, 7.4 versus 7.2 months; OS, 14.9 versus 13.6 months. Mean HRU costs were higher for patients receiving first-line therapy (€7,253.2) compared with those receiving second-line therapy (€6,242.9). Exploratory stratification of outcomes by centre expertise suggested a possible trend towards improved OS in the 10 most experienced centres versus all -others: first-line, 18.4 versus 13.2 months; second-line, 16.4 versus 12.4 months. CONCLUSIONS: In routine care, German clinicians make rational prescribing decisions; possible variations in outcomes between centres warrant further investigation.
OBJECTIVES: To characterize real-world prescribing patterns and their clinical and healthcare resource utilization (HRU) implications in patients with metastatic renal cell carcinoma (mRCC) treated in Germany. METHODS: Eligible individuals were enrolled in the "Bundesverband der Betriebskrankenkassen" claims database and received targeted mRCC therapy between 1 January 2008 and 31 December 2016. Prescribing patterns and HRU were characterized by treatment line and summarized by descriptive statistics. Proxy progression-free survival (PFS) and overall survival (OS) were estimated using Kaplan-Meier curves. RESULTS: 536 patients receiving mRCC treatment were included. The median treatment duration was 4.2 months (interquartile range [IQR]: 1.7-9.3) for first-line therapy and 3.8 months (IQR: 1.7-9.1) for second-line therapy. Median PFS and OS estimates were similar for the first- and second-line treatments: PFS, 7.4 versus 7.2 months; OS, 14.9 versus 13.6 months. Mean HRU costs were higher for patients receiving first-line therapy (€7,253.2) compared with those receiving second-line therapy (€6,242.9). Exploratory stratification of outcomes by centre expertise suggested a possible trend towards improved OS in the 10 most experienced centres versus all -others: first-line, 18.4 versus 13.2 months; second-line, 16.4 versus 12.4 months. CONCLUSIONS: In routine care, German clinicians make rational prescribing decisions; possible variations in outcomes between centres warrant further investigation.
Authors: Peter J Goebell; Michael Staehler; Lothar Müller; Arnd Nusch; Michael Scheffler; Annette Sauer; Ulla von Verschuer; Susanne Tech; Lisa Kruggel; Martina Jänicke; Norbert Marschner Journal: Clin Genitourin Cancer Date: 2018-06-27 Impact factor: 2.872
Authors: Robert J Motzer; Bernard Escudier; Piotr Tomczak; Thomas E Hutson; M Dror Michaelson; Sylvie Negrier; Stephane Oudard; Martin E Gore; Jamal Tarazi; Subramanian Hariharan; Connie Chen; Brad Rosbrook; Sinil Kim; Brian I Rini Journal: Lancet Oncol Date: 2013-04-16 Impact factor: 41.316
Authors: Christian Doehn; Viktor Grünwald; Thomas Steiner; Markus Follmann; Heidrun Rexer; Susanne Krege Journal: Dtsch Arztebl Int Date: 2016-09-05 Impact factor: 5.594
Authors: Christian Beisland; Tom B Johannesen; Olbjorn Klepp; Ulrika Axcrona; Knut Martin Torgersen; Jan Kowalski; Oddvar Solli; Rickard Sandin; Jan Oldenburg Journal: Onco Targets Ther Date: 2017-01-16 Impact factor: 4.147
Authors: Toni K Choueiri; Colin Hessel; Susan Halabi; Ben Sanford; M Dror Michaelson; Olwen Hahn; Meghara Walsh; Thomas Olencki; Joel Picus; Eric J Small; Shaker Dakhil; Darren R Feldman; Milan Mangeshkar; Christian Scheffold; Daniel George; Michael J Morris Journal: Eur J Cancer Date: 2018-03-20 Impact factor: 9.162