Jodie A Schildkraut1, Jack Gallagher2, Kozo Morimoto3, Christoph Lange4, Charles Haworth5, R Andres Floto6, Wouter Hoefsloot7, David E Griffith8, Dirk Wagner9, Jakko van Ingen10. 1. Radboud Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Jodie.Schildkraut@radboudumc.nl. 2. Clarity Pharma Research LLC, Spartanburg, SC, USA. Electronic address: Jgallagher@claritypharma.com. 3. Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. Electronic address: morimotok@fukujuji.org. 4. Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany. Electronic address: clange@fz-borstel.de. 5. Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK. Electronic address: Charles.haworth@nhs.net. 6. Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK. Electronic address: Arf27@cam.ac.uk. 7. Radboud Center for Infectious Diseases, Department of Respiratory Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Wouter.hoefsloot@radboudumc.nl. 8. Department of Pulmonology, University of Texas Health Science Center at Tyler, Tyler, TX, USA. Electronic address: David.griffith@uthct.edu. 9. University Medical Center, Freiburg, Germany. Electronic address: Dirk.wagner@uniklinik-freiburg.de. 10. Radboud Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Jakko.vanIngen@radboudumc.nl.
Abstract
BACKGROUND: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is an emerging opportunistic infection, but basic epidemiological data are lacking in most regions. We have investigated epidemiology and diagnostic and treatment practices in five EU countries (United Kingdom, Spain, Italy, France, Germany; EU5) and Japan. STUDY DESIGN: and methods: Annual prevalence in each country was established using a 2-round Delphi method in combination with a regional prevalence-estimation model that incorporated data obtained from a blinded physician screening survey (3154 physicians) and a real-world NTM-PD treating-physician/patient-chart observational study (619 physicians - 1429 patient charts). RESULTS: The annual prevalence of NTM-PD was estimated at 6.2/100,000 in the EU5 and 24.9/100,000 in Japan. Overall prevalence between the EU5 was comparable, while differences in regional prevalence were found to be pronounced in France and The United Kingdom. Regional differences were also found in Japan, with the majority of cases in Chubu and Kanto regions. CONCLUSION: This new methodology for obtaining often missing regional-level epidemiological data reveals dramatic variations in NTM-PD annual prevalence and helps pinpoint areas that may merit special preventative and treatment focus.
BACKGROUND: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is an emerging opportunistic infection, but basic epidemiological data are lacking in most regions. We have investigated epidemiology and diagnostic and treatment practices in five EU countries (United Kingdom, Spain, Italy, France, Germany; EU5) and Japan. STUDY DESIGN: and methods: Annual prevalence in each country was established using a 2-round Delphi method in combination with a regional prevalence-estimation model that incorporated data obtained from a blinded physician screening survey (3154 physicians) and a real-world NTM-PD treating-physician/patient-chart observational study (619 physicians - 1429 patient charts). RESULTS: The annual prevalence of NTM-PD was estimated at 6.2/100,000 in the EU5 and 24.9/100,000 in Japan. Overall prevalence between the EU5 was comparable, while differences in regional prevalence were found to be pronounced in France and The United Kingdom. Regional differences were also found in Japan, with the majority of cases in Chubu and Kanto regions. CONCLUSION: This new methodology for obtaining often missing regional-level epidemiological data reveals dramatic variations in NTM-PD annual prevalence and helps pinpoint areas that may merit special preventative and treatment focus.
Authors: Jodie Anne Schildkraut; Sanne Maria Henriëtte Zweijpfenning; Martijn Nap; Kun He; Elena Dacheva; Jetty Overbeek; Alma Tostmann; Heiman F L Wertheim; Wouter Hoefsloot; Jakko van Ingen Journal: ERJ Open Res Date: 2021-07-12