| Literature DB >> 32989287 |
Gabriel Cuellar-Partida1,2, Joyce Y Tung2, Nicholas Eriksson2, Eva Albrecht3, Fazil Aliev4,5, Ole A Andreassen6,7, Inês Barroso8,9,10, Jacques S Beckmann11, Marco P Boks12, Dorret I Boomsma13,14, Heather A Boyd15, Monique M B Breteler16, Harry Campbell17, Daniel I Chasman18,19, Lynn F Cherkas20, Gail Davies21,22, Eco J C de Geus13,14, Ian J Deary21,22, Panos Deloukas23, Danielle M Dick4,24, David L Duffy25, Johan G Eriksson26,27,28,29, Tõnu Esko30,31, Bjarke Feenstra15, Frank Geller15, Christian Gieger32,33, Ina Giegling34, Scott D Gordon25, Jiali Han35,36, Thomas F Hansen37,38, Annette M Hartmann34, Caroline Hayward39, Kauko Heikkilä40, Andrew A Hicks41, Joel N Hirschhorn42,43,44, Jouke-Jan Hottenga13,14, Jennifer E Huffman39, Liang-Dar Hwang1, M Arfan Ikram45, Jaakko Kaprio40,46, John P Kemp1,47, Kay-Tee Khaw48, Norman Klopp49, Bettina Konte34, Zoltan Kutalik50,51, Jari Lahti52,53,54, Xin Li35,36, Ruth J F Loos9,55,56, Michelle Luciano21,22, Sigurdur H Magnusson57, Massimo Mangino20, Pedro Marques-Vidal58, Nicholas G Martin25, Wendy L McArdle59, Mark I McCarthy60,61,62,63, Carolina Medina-Gomez45,64, Mads Melbye15,65,66, Scott A Melville41, Andres Metspalu30, Lili Milani30, Vincent Mooser67, Mari Nelis30, Dale R Nyholt25,68, Kevin S O'Connell6, Roel A Ophoff69,70,71, Cameron Palmer72, Aarno Palotie40, Teemu Palviainen40, Guillaume Pare73, Lavinia Paternoster74, Leena Peltonen75, Brenda W J H Penninx14,76, Ozren Polasek77,78, Peter P Pramstaller41, Inga Prokopenko79,80, Katri Raikkonen52, Samuli Ripatti40, Fernando Rivadeneira45,64, Igor Rudan81, Dan Rujescu34, Johannes H Smit14,76, George Davey Smith74, Jordan W Smoller82,83, Nicole Soranzo8, Tim D Spector20, Beate St Pourcain74,84,85, John M Starr86,87, Hreinn Stefánsson57, Stacy Steinberg57, Maris Teder-Laving30, Gudmar Thorleifsson57, Kári Stefánsson57, Nicholas J Timpson74, André G Uitterlinden45,64, Cornelia M van Duijn45,64, Frank J A van Rooij45, Jaqueline M Vink13,88, Peter Vollenweider58, Eero Vuoksimaa40, Gérard Waeber58, Nicholas J Wareham9, Nicole Warrington1, Dawn Waterworth89, Thomas Werge37,65,90, H-Erich Wichmann91, Elisabeth Widen40, Gonneke Willemsen13, Alan F Wright39, Margaret J Wright92,93, Mousheng Xu94, Jing Hua Zhao95, Peter Kraft94, David A Hinds2, Cecilia M Lindgren60,96, Reedik Mägi30, Benjamin M Neale31,97, David M Evans98,99, Sarah E Medland100,101.
Abstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.Entities:
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Year: 2020 PMID： 32989287 PMCID： PMC7116623 DOI： 10.1038/s41562-020-00956-y
Source DB: PubMed Journal: Nat Hum Behav ISSN： 2397-3374