OBJECTIVE: To use functional MRI (fMRI) to further define the occurrence of left-hemisphere, bilateral, and right-hemisphere language in a normal left-handed population. METHODS: A total of 100 healthy volunteers, consisting of 50 left-handed subjects and a reference group of 50 right-handed subjects, were studied by fMRI of the frontal cortex during silent word generation. RESULTS: Ninety-six percent of right-handed subjects showed fMRI changes lateralized to the left hemisphere, whereas 4% showed a bilateral activation pattern. In contrast, left-hemisphere lateralization occurred in 76% of left-handers, bilateral activation in 14%, and right-hemisphere lateralization in the remaining 10%. The predominance of right-hemisphere activation, however, was weak in these cases; only a single left-handed subject (2%) showed complete right-hemisphere lateralization. CONCLUSIONS: Silent word generation lateralizes to the left cerebral hemisphere in both handedness groups, but right-hemisphere participation is frequent in normal left-handed subjects. Exclusive right-hemisphere activation rarely occurred in the frontal lobe region studied.
OBJECTIVE: To use functional MRI (fMRI) to further define the occurrence of left-hemisphere, bilateral, and right-hemisphere language in a normal left-handed population. METHODS: A total of 100 healthy volunteers, consisting of 50 left-handed subjects and a reference group of 50 right-handed subjects, were studied by fMRI of the frontal cortex during silent word generation. RESULTS: Ninety-six percent of right-handed subjects showed fMRI changes lateralized to the left hemisphere, whereas 4% showed a bilateral activation pattern. In contrast, left-hemisphere lateralization occurred in 76% of left-handers, bilateral activation in 14%, and right-hemisphere lateralization in the remaining 10%. The predominance of right-hemisphere activation, however, was weak in these cases; only a single left-handed subject (2%) showed complete right-hemisphere lateralization. CONCLUSIONS: Silent word generation lateralizes to the left cerebral hemisphere in both handedness groups, but right-hemisphere participation is frequent in normal left-handed subjects. Exclusive right-hemisphere activation rarely occurred in the frontal lobe region studied.
Authors: William D Gaillard; Bonnie C Sachs; Joseph R Whitnah; Zaaira Ahmad; Lyn M Balsamo; Jeffrey R Petrella; Suzanne H Braniecki; Christopher M McKinney; Kevin Hunter; Ben Xu; Cecile B Grandin Journal: Hum Brain Mapp Date: 2003-03 Impact factor: 5.038
Authors: Andreas Jansen; Agnes Flöel; Michael Deppe; Jutta van Randenborgh; Bianca Dräger; Martin Kanowski; Stefan Knecht Journal: Hum Brain Mapp Date: 2004-11 Impact factor: 5.038
Authors: Mohamed L Seghier; François Lazeyras; Alan J Pegna; Jean-Marie Annoni; Ivan Zimine; Eugène Mayer; Christoph M Michel; Asaid Khateb Journal: Hum Brain Mapp Date: 2004-11 Impact factor: 5.038
Authors: Madison M Berl; Jessica Mayo; Erin N Parks; Lisa R Rosenberger; John VanMeter; Nan Bernstein Ratner; Chandan J Vaidya; William Davis Gaillard Journal: Hum Brain Mapp Date: 2012-10-03 Impact factor: 5.038
Authors: Yu-Hsuan A Chang; Nobuko Kemmotsu; Kelly M Leyden; N Erkut Kucukboyaci; Vicente J Iragui; Evelyn S Tecoma; Leena Kansal; Marc A Norman; Rachelle Compton; Tobin J Ehrlich; Vedang S Uttarwar; Anny Reyes; Brianna M Paul; Carrie R McDonald Journal: Brain Lang Date: 2017-04-20 Impact factor: 2.381