| Literature DB >> 32989263 |
Junho Bang1,2, Chang Hun Hwang1,2, Jung Ho Ahn1,2, Jong An Lee1,2, Sang Yup Lee3,4,5.
Abstract
We engineered Escherichia coli to grow on CO2 and formic acid alone by introducing the synthetic CO2 and formic acid assimilation pathway, expressing two formate dehydrogenase genes, fine-tuning metabolic fluxes and optimizing the levels of cytochrome bo3 and bd-I ubiquinol oxidase. Our engineered strain can grow to an optical density at 600 nm of 7.38 in 450 h, and shows promise as a platform strain growing on CO2 and formic acid alone.Entities:
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Year: 2020 PMID： 32989263 DOI： 10.1038/s41564-020-00793-9
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745