Literature DB >> 32988818

Planktonic and Biofilm Activity of Eravacycline against Staphylococci Isolated from Periprosthetic Joint Infections.

Georg Zhuchenko1, Suzannah Schmidt-Malan1, Robin Patel2,3.   

Abstract

MIC and minimum biofilm bactericidal concentration (MBBC) values of eravacycline against 185 staphylococci from periprosthetic joint infections were determined. Staphylococcus aureus had MICs of ≤0.25 μg/ml. MICs for methicillin-susceptible and -resistant Staphylococcus epidermidis were ≤1 and ≤2 μg/ml, respectively. S. aureus and S. epidermidis MBBC50 and MBBC90 values were 8 and 16 μg/ml for each, showing poor anti-staphylococcal biofilm activity using the method studied.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  biofilm; biofilm susceptibility; eravacycline; periprosthetic joint infection; staphylococci

Mesh：

Substances：

Year:  2020        PMID： 32988818      PMCID： PMC7674029          DOI： 10.1128/AAC.01304-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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6.  Periprosthetic joint infection: the incidence, timing, and predisposing factors.

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8.  The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms.

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Review 10.  Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity.

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  1 in total

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