Anirudh Bhimavarapu1, Qiao Deng2, Marta Bean3, Nick Lee4, Thomas R Ziegler5, Jessica Alvarez6, Vin Tangpricha7. 1. Emory College of Arts & Sciences, Emory University, Atlanta, GA, United States. 2. Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, United States. 3. Emory University School of Medicine, Emory University, Atlanta, GA, United States. 4. Goizueta Business School, Emory University, Atlanta, GA, United States. 5. Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA, United States; Atlanta VA Medical Center, Atlanta, GA, United States. 6. Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA, United States. 7. Nutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University, Atlanta, GA, United States; Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA, United States; Atlanta VA Medical Center, Atlanta, GA, United States. Electronic address: vin.tangpricha@emory.edu.
Abstract
BACKGROUND: Individuals with cystic fibrosis (CF) have difficulty maintaining optimal vitamin D status due to pancreatic insufficiency-induced malabsorption, inadequate sunlight exposure, and poor intake of vitamin D containing foods. Vitamin D deficiency may increase the risk of pulmonary exacerbations of CF. The objective of this study was to assess factors impacting vitamin D status in patients with CF recently hospitalized for a pulmonary exacerbation of CF. METHODS: This was a pre-planned analysis of vitamin D intake in patients enrolled in a multi-center, double-blind, randomized controlled study examining vitamin D therapy for pulmonary exacerbation of CF. Demographic information, responses from a habitual sun exposure questionnaire and food frequency questionnaire, and vitamin D supplement usage were queried and compared to serum 25-hydroxyvitamin D (25(OH)D) concentrations. RESULTS: A total of 48 subjects were included in this analysis. Subjects were taking approximately 1,200 IU of vitamin D daily. Reported vitamin D intake, age, race, employment, and education were not significantly associated with vitamin D status in this population. However, smoking status, sunlight exposure in the last 3 years, and skin type (in the bivariate model) were all significantly associated with vitamin D status (all p<0.05). CONCLUSIONS: Sunlight exposure was the most predictive determinant of vitamin D status in patients with CF prior to pulmonary exacerbation. Subjects reported vitamin D intake below the recommended amounts. The role and mode of optimizing vitamin D status prior to a pulmonary exacerbation needs further investigation. Published by Elsevier Inc.
BACKGROUND: Individuals with cystic fibrosis (CF) have difficulty maintaining optimal vitamin D status due to pancreatic insufficiency-induced malabsorption, inadequate sunlight exposure, and poor intake of vitamin D containing foods. Vitamin D deficiency may increase the risk of pulmonary exacerbations of CF. The objective of this study was to assess factors impacting vitamin D status in patients with CF recently hospitalized for a pulmonary exacerbation of CF. METHODS: This was a pre-planned analysis of vitamin D intake in patients enrolled in a multi-center, double-blind, randomized controlled study examining vitamin D therapy for pulmonary exacerbation of CF. Demographic information, responses from a habitual sun exposure questionnaire and food frequency questionnaire, and vitamin D supplement usage were queried and compared to serum 25-hydroxyvitamin D (25(OH)D) concentrations. RESULTS: A total of 48 subjects were included in this analysis. Subjects were taking approximately 1,200 IU of vitamin D daily. Reported vitamin D intake, age, race, employment, and education were not significantly associated with vitamin D status in this population. However, smoking status, sunlight exposure in the last 3 years, and skin type (in the bivariate model) were all significantly associated with vitamin D status (all p<0.05). CONCLUSIONS: Sunlight exposure was the most predictive determinant of vitamin D status in patients with CF prior to pulmonary exacerbation. Subjects reported vitamin D intake below the recommended amounts. The role and mode of optimizing vitamin D status prior to a pulmonary exacerbation needs further investigation. Published by Elsevier Inc.
Entities:
Keywords:
Cystic fibrosis; Nutrition; Pulmonary exacerbation; Vitamin D
Authors: Linda L Wolfenden; Suzanne E Judd; Reshma Shah; Rupan Sanyal; Thomas R Ziegler; Vin Tangpricha Journal: Clin Endocrinol (Oxf) Date: 2008-02-11 Impact factor: 3.478
Authors: Jessica A Alvarez; Ritam Chowdhury; Dean P Jones; Greg S Martin; Kenneth L Brigham; José N Binongo; Thomas R Ziegler; Vin Tangpricha Journal: Clin Endocrinol (Oxf) Date: 2014-04-15 Impact factor: 3.478
Authors: Vin Tangpricha; Ellen M Smith; Jose Binongo; Suzanne E Judd; Thomas R Ziegler; Seth Walker; Rabindra Tirouvanziam; Susu M Zughaier; Moon Jeong Lee; Supavit Chesdachai; Wendy A Hermes; James F Chmiel; Amit Gaggar; Ruth E Grossmann; Patricia M Joseph; Jessica A Alvarez Journal: Contemp Clin Trials Commun Date: 2017-03-09