Literature DB >> 3297674

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

J A Garcia-Sanz, G Plaetinck, F Velotti, D Masson, J Tschopp, H R MacDonald, M Nabholz.   

Abstract

We show that among the subsets of peripheral T lymphocytes (Lyt2+ L3T4- and L3T4+ Lyt2- cells) activated in short-term cultures by stimulation with H-2 incompatible leukocytes 97% of the cytolytic activity and all detectable perforin activity resides in the Lyt2+ cells. But both populations contain approximately equal amounts of a serine protease, granzyme A, the expression of which was previously thought to be restricted to cytolytic T lymphocytes.

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Year:  1987        PMID： 3297674      PMCID： PMC553485          DOI： 10.1002/j.1460-2075.1987.tb04841.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  37 in total

1.  Conjugate formation by primary and secondary populations of murine immune T lymphocytes.

Authors:  A L Glasebrook
Journal:  J Immunol       Date:  1978-11       Impact factor: 5.422

2.  Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.

Authors:  J C Alwine; D J Kemp; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  Light scatter analysis and sorting of cells activated in mixed leukocyte culture.

Authors:  H R MacDonald; P Zaech
Journal:  Cytometry       Date:  1982-07

4.  H-2 antigen-specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequency.

Authors:  M J Bevan; R E Langman; M Cohn
Journal:  Eur J Immunol       Date:  1976-03       Impact factor: 5.532

Review 5.  Mechanism of specific tumor-cell lysis by alloimmune T lymphocytes: resolution and characterization of discrete steps in the cellular interaction.

Authors:  E Martz
Journal:  Contemp Top Immunobiol       Date:  1977

6.  Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.

Authors:  T W Chang; H N Eisen
Journal:  J Immunol       Date:  1980-03       Impact factor: 5.422

7.  Establishment of B cell hybridomas with B cell surface antigens.

Authors:  T Hamano; K J Kim; W M Leiserson; R Asofsky
Journal:  J Immunol       Date:  1982-10       Impact factor: 5.422

8.  Precursor frequency analysis of lymphokine-secreting alloreactive T lymphocytes. Dissociation of subsets producing interleukin 2, macrophage-activating factor, and granulocyte-macrophage colony-stimulating factor on the basis of Lyt-2 phenotype.

Authors:  A Kelso; H R Macdonald
Journal:  J Exp Med       Date:  1982-11-01       Impact factor: 14.307

9.  Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

Authors:  N Borregaard; J M Heiple; E R Simons; R A Clark
Journal:  J Cell Biol       Date:  1983-07       Impact factor: 10.539

10.  Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures.

Authors:  J C Cerottini; H D Engers; H R Macdonald; T Brunner
Journal:  J Exp Med       Date:  1974-09-01       Impact factor: 14.307
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  14 in total

1.  Ultrastructural changes during lysis of L929 target cells by class II-restricted influenza virus-specific murine cytotoxic T-lymphocyte clones.

Authors:  N Ono; K K Ko; Y Hosaka
Journal:  J Virol       Date:  1990-05       Impact factor: 5.103

2.  Theiler's virus infection of perforin-deficient mice.

Authors:  C P Rossi; A McAllister; M Tanguy; D Kägi; M Brahic
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

3.  Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli.

Authors:  J A Garcia-Sanz; F Velotti; H R MacDonald; D Masson; J Tschopp; M Nabholz
Journal:  Immunology       Date:  1988-05       Impact factor: 7.397

4.  Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes.

Authors:  D Jenne; C Rey; J A Haefliger; B Y Qiao; P Groscurth; J Tschopp
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

5.  Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanisms.

Authors:  D S Ucker; J D Wilson; L D Hebshi
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

6.  Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis.

Authors:  D C Nordström; Y T Konttinen; T Sorsa; P Nykanen; T Pettersson; S Santavirta; J Tschopp
Journal:  Clin Rheumatol       Date:  1992-12       Impact factor: 2.980

7.  T cells cause acute immunopathology and are required for long-term survival in mouse adenovirus type 1-induced encephalomyelitis.

Authors:  Martin L Moore; Corrie C Brown; Katherine R Spindler
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

8.  Heterogeneity of murine adherent interleukin-2-activated killer cells. Differential effect of prostaglandin E2 and forskolin.

Authors:  D Vaillier; R Daculsi; N Gualde
Journal:  Cancer Immunol Immunother       Date:  1995-01       Impact factor: 6.968

9.  Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.

Authors:  H Acha-Orbea; L Scarpellino; S Hertig; M Dupuis; J Tschopp
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598

10.  Serine esterase and hemolytic activity in human cloned cytotoxic T lymphocytes.

Authors:  W S Ferguson; C R Verret; E B Reilly; M J Iannini; H N Eisen
Journal:  J Exp Med       Date:  1988-02-01       Impact factor: 14.307
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