Literature DB >> 32975103

Skin burns from monochloroacetic acid leak in a chemical plant: a case report.

Yiming Tao1, Tingting Liu1, Xiangdong Jian1.   

Abstract

The patient, a 45-year-old male chemical factory worker, was burned by monochloroacetic acid discharged from a ruptured pipe. The patient was merely flushed with water and did not leave the workplace immediately. As a result, he suffered local burn symptoms, which gradually worsened. Two and a half hours after the accident, he developed symptoms of systemic poisoning, such as lethargy and dyspnoea. After a thorough debridement of the wound surface and subsequent skin grafting combined with early glucocorticoid therapy and haemofiltration, a satisfactory result was achieved, and the patient eventually recovered. With the widespread use of monochloroacetic acid in China, incidents of poisoning with this chemical are becoming increasingly common, with more than 100 cases reported in the past ten years in China alone.

Entities:  

Keywords:  chemical burn; continuous renal replacement therapy; occupational accident; poisoning

Mesh:

Substances:

Year:  2020        PMID: 32975103      PMCID: PMC7968492          DOI: 10.2478/aiht-2020-71-3401

Source DB:  PubMed          Journal:  Arh Hig Rada Toksikol        ISSN: 0004-1254            Impact factor:   2.078


  15 in total

1.  Theoretical Investigations on the Mechanism and Kinetics of OH Radical Initiated Reactions of Monochloroacetic Acid.

Authors:  R Bhuvaneswari; L Sandhiya; K Senthilkumar
Journal:  J Phys Chem A       Date:  2017-08-02       Impact factor: 2.781

2.  Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase.

Authors:  Akiko Sakai; Hiroyasu Shimizu; Koichi Kono; Eisuke Furuya
Journal:  Chem Res Toxicol       Date:  2005-02       Impact factor: 3.739

3.  Kinetics of monochloroacetic acid in adult male rats after intravenous injection of a subtoxic and a toxic dose.

Authors:  S A Saghir; K Fried; K K Rozman
Journal:  J Pharmacol Exp Ther       Date:  2001-02       Impact factor: 4.030

4.  Toxicology of chlorinated paraffins.

Authors:  D M Serrone; R D Birtley; W Weigand; R Millischer
Journal:  Food Chem Toxicol       Date:  1987-07       Impact factor: 6.023

5.  Systemic treatment for severe concentrated sulfuric acid burns in an adult male at high altitude: A case report.

Authors:  Ruo-Mei Zhao; Yi Li; Sheng-Wu Chao; Hong-Jin Wang
Journal:  World J Clin Cases       Date:  2020-04-06       Impact factor: 1.337

6.  Monochloroacetic acid exposure: a case report.

Authors:  G D Kusch; L P McCarty; J M Lanham
Journal:  Pol J Occup Med       Date:  1990

7.  Systemic effects and skin injury after experimental dermal exposure to monochloroacetic acid.

Authors:  Tomotaro Dote; Koichi Kono; Kan Usuda; Hiroyasu Shimizu; Yoshimi Tanimoto; Emi Dote; Satsuki Hayashi
Journal:  Toxicol Ind Health       Date:  2003-10       Impact factor: 2.273

8.  Kinetics of monochloroacetic acid at subtoxic and toxic doses in rats after single oral and dermal administrations.

Authors:  Shakil A Saghir; Karl K Rozman
Journal:  Toxicol Sci       Date:  2003-08-12       Impact factor: 4.849

9.  Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals.

Authors:  Chun-Hung Chen; Sz-Jie Chen; Chin-Chuan Su; Cheng-Chieh Yen; To-Jung Tseng; Tzyy-Rong Jinn; Feng-Cheng Tang; Kuo-Liang Chen; Yi-Chang Su; kuan-I Lee; Dong-Zong Hung; Chun-Fa Huang
Journal:  Toxicology       Date:  2012-10-26       Impact factor: 4.221

10.  Fatal systemic poisoning after skin exposure to monochloroacetic acid.

Authors:  P Kulling; H Andersson; K Boström; L A Johansson; B Lindström; B Nyström
Journal:  J Toxicol Clin Toxicol       Date:  1992
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