Sophie C H Van Malderen1,2, Carl J Schultz3,4, Luc Jordaens1. 1. Department of Cardiology, Erasmus MC, Dr. Molewaterplein 40. 3015 GD, Rotterdam, The Netherlands. 2. Department of Cardiology, AZ Monica, Florent Pauwelslei 1, 2100, Deurne, Belgium. 3. School of Medicine, University of Western Australia, Perth, Western Australia, Australia. 4. Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia.
Abstract
BACKGROUND: Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular tachycardia or fibrillation (VF). CASE SUMMARY: A 72-year-old woman with BS and a stenosis on the proximal right coronary artery received several subsequent implantable cardioverter-defibrillator shocks due to VF during an episode of extreme nausea with vomiting. DISCUSSION: This case report emphasizes on the synergetic effect of mild ischaemia and increased vagal tone on the substrate responsible for BS to create pathophysiological changes precipitating VF.
BACKGROUND: Brugada syndrome (BS) is a hereditary channelopathy associated with syncope, malignant ventricular arrhythmia, and sudden cardiac death. Right ventricular ischaemia and BS have similar underlying substrates precipitating ventricular tachycardia or fibrillation (VF). CASE SUMMARY: A 72-year-old woman with BS and a stenosis on the proximal right coronary artery received several subsequent implantable cardioverter-defibrillator shocks due to VF during an episode of extreme nausea with vomiting. DISCUSSION: This case report emphasizes on the synergetic effect of mild ischaemia and increased vagal tone on the substrate responsible for BS to create pathophysiological changes precipitating VF.
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