Jon Magne Letnes1, Håvard Dalen2, Stian Thoresen Aspenes3, Øyvind Salvesen4, Ulrik Wisløff5, Bjarne Martens Nes6. 1. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Cardiology, St. Olavs University Hospital, Trondheim, Norway. 2. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Cardiology, St. Olavs University Hospital, Trondheim, Norway; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway. 3. Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. 4. Unit of Applied Clinical Research, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. 5. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; School of Human Movement and Nutrition Science, University of Queensland, Queensland, Australia. 6. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Cardiology, St. Olavs University Hospital, Trondheim, Norway. Electronic address: bjarne.nes@ntnu.no.
Abstract
BACKGROUND: Large longitudinal studies on change in directly measured peak oxygen uptake (VO2peak) is lacking, and its significance for change of cardiovascular risk factors is uncertain. We aimed to assess ten-year change in VO2peak and the influence of leisure-time physical activity (LTPA), and the association between change in VO2peak and change in cardiovascular risk factors. METHODS AND RESULTS: A healthy general population sample had their VO2peak directly measured in two (n = 1431) surveys of the Nord-Trøndelag Health Study (HUNT3; 2006-2008 and HUNT4; 2017-19). Average ten-year decline in VO2peak was non-linear and progressed from 3% in the third to about 20% in the eight decade in life and was more pronounced in men. The fit linear mixed models including an additional 2,933 observations from subjects participating only in HUNT3 showed similar age-related decline. Self-reported adherence to LTPA recommendations was associated with better maintenance of VO2peak, with intensity seemingly more important than minutes of LTPA with higher age. Adjusted linear regression analyses showed that one mL/kg/min better maintenance of VO2peak was associated with favorable changes of individual cardiovascular risk factors (all p ≤ 0.002). Using logistic regression one mL/kg/min better maintenance of VO2peak was associated with lower adjusted odds ratio of hypertension (0.95 95% CI 0.92 to 0.98), dyslipidemia (0.92 95% CI 0.89 to 0.94), and metabolic syndrome (0.86 95% CI 0.83 to 0.90) at follow-up. CONCLUSIONS: Although VO2peak declines progressively with age, performing LTPA and especially high-intensity LTPA is associated with less decline. Maintaining VO2peak is associated with an improved cardiovascular risk profile.
BACKGROUND: Large longitudinal studies on change in directly measured peak oxygen uptake (VO2peak) is lacking, and its significance for change of cardiovascular risk factors is uncertain. We aimed to assess ten-year change in VO2peak and the influence of leisure-time physical activity (LTPA), and the association between change in VO2peak and change in cardiovascular risk factors. METHODS AND RESULTS: A healthy general population sample had their VO2peak directly measured in two (n = 1431) surveys of the Nord-Trøndelag Health Study (HUNT3; 2006-2008 and HUNT4; 2017-19). Average ten-year decline in VO2peak was non-linear and progressed from 3% in the third to about 20% in the eight decade in life and was more pronounced in men. The fit linear mixed models including an additional 2,933 observations from subjects participating only in HUNT3 showed similar age-related decline. Self-reported adherence to LTPA recommendations was associated with better maintenance of VO2peak, with intensity seemingly more important than minutes of LTPA with higher age. Adjusted linear regression analyses showed that one mL/kg/min better maintenance of VO2peak was associated with favorable changes of individual cardiovascular risk factors (all p ≤ 0.002). Using logistic regression one mL/kg/min better maintenance of VO2peak was associated with lower adjusted odds ratio of hypertension (0.95 95% CI 0.92 to 0.98), dyslipidemia (0.92 95% CI 0.89 to 0.94), and metabolic syndrome (0.86 95% CI 0.83 to 0.90) at follow-up. CONCLUSIONS: Although VO2peak declines progressively with age, performing LTPA and especially high-intensity LTPA is associated with less decline. Maintaining VO2peak is associated with an improved cardiovascular risk profile.
Authors: Matthew Nayor; Ariel Chernofsky; Nicole L Spartano; Melissa Tanguay; Jasmine B Blodgett; Venkatesh L Murthy; Rajeev Malhotra; Nicholas E Houstis; Raghava S Velagaleti; Joanne M Murabito; Martin G Larson; Ramachandran S Vasan; Ravi V Shah; Gregory D Lewis Journal: Eur Heart J Date: 2021-11-21 Impact factor: 35.855
Authors: Jon Magne Letnes; Ida Berglund; Kristin E Johnson; Håvard Dalen; Bjarne M Nes; Stian Lydersen; Hallgeir Viken; Erlend Hassel; Sigurd Steinshamn; Elisabeth Kleivhaug Vesterbekkmo; Asbjørn Støylen; Line S Reitlo; Nina Zisko; Fredrik H Bækkerud; Atefe R Tari; Jan Erik Ingebrigtsen; Silvana B Sandbakk; Trude Carlsen; Sigmund A Anderssen; Maria A Fiatarone Singh; Jeff S Coombes; Jorunn L Helbostad; Øivind Rognmo; Ulrik Wisløff; Dorthe Stensvold Journal: Eur Heart J Date: 2022-06-01 Impact factor: 35.855
Authors: Jenna L Taylor; Jose R Medina-Inojosa; Audry Chacin-Suarez; Joshua R Smith; Ray W Squires; Randal J Thomas; Bruce D Johnson; Thomas P Olson; Amanda R Bonikowske Journal: Front Cardiovasc Med Date: 2022-04-14