Literature DB >> 32967944

Microsatellite instability driven metastatic parathyroid carcinoma managed with the anti-PD1 immunotherapy, pembrolizumab.

Daniel Park1, Rany Airi2, Michael Sherman3.   

Abstract

The present case report describes a 65-year-old man with Lynch syndrome and hypercalcaemia associated with hyperparathyroidism. Parathyroid surgery confirmed the diagnosis of parathyroid carcinoma. Serum calcium and parathyroid hormone (PTH) concentrations serially increased after initial surgery. Imaging study and subsequent biopsy confirmed lung metastases with mismatch repair deficiency. Pembrolizumab was initiated achieving 60% reduction in tumour burden. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  cancer intervention; oncology

Mesh：

Substances：

Year:  2020        PMID： 32967944      PMCID： PMC7513558          DOI： 10.1136/bcr-2020-235293

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  8 in total

1.  Effector memory T cells, early metastasis, and survival in colorectal cancer.

Authors:  Franck Pagès; Anne Berger; Matthieu Camus; Fatima Sanchez-Cabo; Anne Costes; Robert Molidor; Bernhard Mlecnik; Amos Kirilovsky; Malin Nilsson; Diane Damotte; Tchao Meatchi; Patrick Bruneval; Paul-Henri Cugnenc; Zlatko Trajanoski; Wolf-Herman Fridman; Jérôme Galon
Journal:  N Engl J Med       Date:  2005-12-22       Impact factor: 91.245

2.  Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

Authors:  Dung T Le; Jennifer N Durham; Kellie N Smith; Hao Wang; Bjarne R Bartlett; Laveet K Aulakh; Steve Lu; Holly Kemberling; Cara Wilt; Brandon S Luber; Fay Wong; Nilofer S Azad; Agnieszka A Rucki; Dan Laheru; Ross Donehower; Atif Zaheer; George A Fisher; Todd S Crocenzi; James J Lee; Tim F Greten; Austin G Duffy; Kristen K Ciombor; Aleksandra D Eyring; Bao H Lam; Andrew Joe; S Peter Kang; Matthias Holdhoff; Ludmila Danilova; Leslie Cope; Christian Meyer; Shibin Zhou; Richard M Goldberg; Deborah K Armstrong; Katherine M Bever; Amanda N Fader; Janis Taube; Franck Housseau; David Spetzler; Nianqing Xiao; Drew M Pardoll; Nickolas Papadopoulos; Kenneth W Kinzler; James R Eshleman; Bert Vogelstein; Robert A Anders; Luis A Diaz
Journal:  Science       Date:  2017-06-08       Impact factor: 47.728

3.  The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.

Authors:  Nicolas J Llosa; Michael Cruise; Ada Tam; Elizabeth C Wicks; Elizabeth M Hechenbleikner; Janis M Taube; Richard L Blosser; Hongni Fan; Hao Wang; Brandon S Luber; Ming Zhang; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Cynthia L Sears; Robert A Anders; Drew M Pardoll; Franck Housseau
Journal:  Cancer Discov       Date:  2014-10-30       Impact factor: 39.397

Review 4.  Parathyroid carcinoma: Challenges in diagnosis and treatment.

Authors:  Daniela Betea; Iulia Potorac; Albert Beckers
Journal:  Ann Endocrinol (Paris)       Date:  2015-04-21       Impact factor: 2.478

Review 5.  A practical approach to hypercalcemia.

Authors:  Mary F Carroll; David S Schade
Journal:  Am Fam Physician       Date:  2003-05-01       Impact factor: 3.292

Review 6.  Microsatellite Instability as a Biomarker for PD-1 Blockade.

Authors:  Jonathan C Dudley; Ming-Tseh Lin; Dung T Le; James R Eshleman
Journal:  Clin Cancer Res       Date:  2016-02-15       Impact factor: 12.531

7.  Genotype of CDC73 germline mutation determines risk of parathyroid cancer.

Authors:  Yulong Li; Jianhua Zhang; Poorni R Adikaram; James Welch; Bin Guan; Lee S Weinstein; Haobin Chen; William F Simonds
Journal:  Endocr Relat Cancer       Date:  2020-09       Impact factor: 5.678

8.  Long-term remission of disseminated parathyroid cancer following immunotherapy.

Authors:  Marta Sarquis; Stephen J Marx; Albert Beckers; Arthur R Bradwell; William F Simonds; Maria Aparecida C Bicalho; Adrian F Daly; Daniela Betea; Eitan Friedman; Luiz De Marco
Journal:  Endocrine       Date:  2019-11-28       Impact factor: 3.925
  8 in total
  2 in total

1.  Treatment and outcome of metastatic parathyroid carcinoma: A systematic review and pooled analysis of published cases.

Authors:  Andrea Alberti; Davide Smussi; Manuel Zamparini; Antonella Turla; Lara Laini; Chiara Marchiselli; Salvatore Grisanti; Paolo Bossi; Alfredo Berruti
Journal:  Front Oncol       Date:  2022-09-26       Impact factor: 5.738

2.  Commentary: Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management.

Authors:  Giuseppe Fanciulli; Sergio Di Molfetta; Andrea Dotto; Tullio Florio; Tiziana Feola; Annamaria Colao; Antongiulio Faggiano
Journal:  Front Endocrinol (Lausanne)       Date:  2021-06-18       Impact factor: 5.555
  2 in total

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