MOTIVATION: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. RESULTS: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks. AVAILABILITY AND IMPLEMENTATION: https://github.com/isglobal-brge/methylclock. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
MOTIVATION: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. RESULTS: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks. AVAILABILITY AND IMPLEMENTATION: https://github.com/isglobal-brge/methylclock. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: Ireen Klemp; Anne Hoffmann; Luise Müller; Tobias Hagemann; Kathrin Horn; Kerstin Rohde-Zimmermann; Anke Tönjes; Joachim Thiery; Markus Löffler; Ralph Burkhardt; Yvonne Böttcher; Michael Stumvoll; Matthias Blüher; Knut Krohn; Markus Scholz; Ronny Baber; Paul W Franks; Peter Kovacs; Maria Keller Journal: Clin Transl Med Date: 2022-06
Authors: Giulietta S Monasso; Leanne K Küpers; Vincent W V Jaddoe; Sandra G Heil; Janine F Felix Journal: Clin Epigenetics Date: 2021-04-29 Impact factor: 6.551