Hoger Amin1,2, Anthi A Apostolopoulou1,2, Raquel Suárez-Grimalt1, Eleftheria Vrontou3, Andrew C Lin1,2. 1. Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom. 2. Neuroscience Institute, University of Sheffield, Sheffield, United Kingdom. 3. Centre for Neural Circuits and Behaviour, University of Oxford, Oxford, United Kingdom.
Abstract
Many neurons show compartmentalized activity, in which activity does not spread readily across the cell, allowing input and output to occur locally. However, the functional implications of compartmentalized activity for the wider neural circuit are often unclear. We addressed this problem in the Drosophila mushroom body, whose principal neurons, Kenyon cells, receive feedback inhibition from a non-spiking interneuron called the anterior paired lateral (APL) neuron. We used local stimulation and volumetric calcium imaging to show that APL inhibits Kenyon cells' dendrites and axons, and that both activity in APL and APL's inhibitory effect on Kenyon cells are spatially localized (the latter somewhat less so), allowing APL to differentially inhibit different mushroom body compartments. Applying these results to the Drosophila hemibrain connectome predicts that individual Kenyon cells inhibit themselves via APL more strongly than they inhibit other individual Kenyon cells. These findings reveal how cellular physiology and detailed network anatomy can combine to influence circuit function.
Many neurons show compartmentalized activity, in which activity does not spread readilyacross the cell, allowing input and output to occur locally. However, the functional implications of compartmentalized activity for the wider neural circuit are often unclear. We addressed this problem in the Drosophilapan>n class="Species">mushroom body, whose principal neurons, Kenyon cells, receive feedback inhibition from a non-spiking interneuron called the anterior paired lateral (APL) neuron. We used local stimulation and volumetric calcium imaging to show that APL inhibits Kenyon cells' dendrites and axons, and that both activity in APL and APL's inhibitory effect on Kenyon cells are spatially localized (the latter somewhat less so), allowing APL to differentially inhibit different mushroom body compartments. Applying these results to the Drosophila hemibrain connectome predicts that individual Kenyon cells inhibit themselves via APL more strongly than they inhibit other individual Kenyon cells. These findings reveal how cellular physiology and detailed network anatomy can combine to influence circuit function.
Authors: Yoshinori Aso; Daisuke Hattori; Yang Yu; Rebecca M Johnston; Nirmala A Iyer; Teri-T B Ngo; Heather Dionne; L F Abbott; Richard Axel; Hiromu Tanimoto; Gerald M Rubin Journal: Elife Date: 2014-12-23 Impact factor: 8.140
Authors: Zhihao Zheng; J Scott Lauritzen; Eric Perlman; Camenzind G Robinson; Matthew Nichols; Daniel Milkie; Omar Torrens; John Price; Corey B Fisher; Nadiya Sharifi; Steven A Calle-Schuler; Lucia Kmecova; Iqbal J Ali; Bill Karsh; Eric T Trautman; John A Bogovic; Philipp Hanslovsky; Gregory S X E Jefferis; Michael Kazhdan; Khaled Khairy; Stephan Saalfeld; Richard D Fetter; Davi D Bock Journal: Cell Date: 2018-07-19 Impact factor: 41.582