Literature DB >> 32944639

Oncogenic pathway driven by p85β: upstream signals to activate p110.

Ling Rao1, Lydia W T Cheung1.   

Abstract

The phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectional regulation between PI3K and RTK.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  AXL; PI3K; autophagy; p85; protein degradation

Year:  2020        PMID： 32944639      PMCID： PMC7469557          DOI： 10.1080/23723556.2020.1780900

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The phosphoinositide 3-kinase pathway.

Authors:  Lewis C Cantley
Journal:  Science       Date:  2002-05-31       Impact factor: 47.728

2.  Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation.

Authors:  Paloma Valverde
Journal:  Biochem Biophys Res Commun       Date:  2005-07-22       Impact factor: 3.575

3.  p85β phosphoinositide 3-kinase subunit regulates tumor progression.

Authors:  Isabel Cortés; Jesús Sánchez-Ruíz; Susana Zuluaga; Vincenzo Calvanese; Miriam Marqués; Carmen Hernández; Teresa Rivera; Leonor Kremer; Ana González-García; Ana C Carrera
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-25       Impact factor: 11.205

4.  Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit.

Authors:  J Yu; Y Zhang; J McIlroy; T Rordorf-Nikolic; G A Orr; J M Backer
Journal:  Mol Cell Biol       Date:  1998-03       Impact factor: 4.272

5.  Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking.

Authors:  M Dean Chamberlain; Jennifer C Oberg; Levi A Furber; Sharon F Poland; Andrea D Hawrysh; Stacey M Knafelc; Heidi M McBride; Deborah H Anderson
Journal:  Cell Signal       Date:  2010-06-04       Impact factor: 4.315

6.  AXL is an essential factor and therapeutic target for metastatic ovarian cancer.

Authors:  Erinn B Rankin; Katherine C Fuh; Tiffany E Taylor; Adam J Krieg; Margaret Musser; Jenny Yuan; Kevin Wei; Calvin J Kuo; Teri A Longacre; Amato J Giaccia
Journal:  Cancer Res       Date:  2010-09-21       Impact factor: 12.701

7.  Computational and Immunohistochemical Analyses Highlight AXL as a Potential Prognostic Marker for Ovarian Cancer Patients.

Authors:  Ludmila Lozneanu; Patrizia Pinciroli; Delia Apostol Ciobanu; Maria Luisa Carcangiu; Silvana Canevari; Antonella Tomassetti; Irina-Draga Căruntu
Journal:  Anticancer Res       Date:  2016-08       Impact factor: 2.480

8.  p85β regulates autophagic degradation of AXL to activate oncogenic signaling.

Authors:  Ling Rao; Victor C Y Mak; Yuan Zhou; Dong Zhang; Xinran Li; Chloe C Y Fung; Rakesh Sharma; Chao Gu; Yiling Lu; George L Tipoe; Annie N Y Cheung; Gordon B Mills; Lydia W T Cheung
Journal:  Nat Commun       Date:  2020-05-08       Impact factor: 14.919

9.  The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

Authors:  Magdalena Paolino; Axel Choidas; Stephanie Wallner; Blanka Pranjic; Iris Uribesalgo; Stefanie Loeser; Amanda M Jamieson; Wallace Y Langdon; Fumiyo Ikeda; Juan Pablo Fededa; Shane J Cronin; Roberto Nitsch; Carsten Schultz-Fademrecht; Jan Eickhoff; Sascha Menninger; Anke Unger; Robert Torka; Thomas Gruber; Reinhard Hinterleitner; Gottfried Baier; Dominik Wolf; Axel Ullrich; Bert M Klebl; Josef M Penninger
Journal:  Nature       Date:  2014-02-19       Impact factor: 49.962

10.  Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium.

Authors:  Lydia W T Cheung; Katarzyna W Walkiewicz; Tabot M D Besong; Huifang Guo; David H Hawke; Stefan T Arold; Gordon B Mills
Journal:  Elife       Date:  2015-07-29       Impact factor: 8.140
  10 in total
  1 in total

1.  CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.

Authors:  Xuehui Wang; Wei Jian; Qifeng Luo; Lin Fang
Journal:  Cell Death Dis       Date:  2022-09-17       Impact factor: 9.685
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.