Literature DB >> 12040186

The phosphoinositide 3-kinase pathway.

Lewis C Cantley1.   

Abstract

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

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Year:  2002        PMID： 12040186     DOI： 10.1126/science.296.5573.1655

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  1816 in total

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