Xiaoyan Fan1,2, Yuelei Jin1, Guang Chen1, Xueqiang Ma3, Lixia Zhang4. 1. Department of Basic Medical Sciences, Taizhou University Hospital, Taizhou University, Taizhou, China. 2. Department of Neurology, Taizhou Second People's Hospital, Taizhou, China. 3. Department of Gastrointestinal Surgery, Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou, China. 4. Department of Neurology, Taizhou Second People's Hospital, Taizhou, China, zhlixia11111@163.com.
Abstract
BACKGROUND: The gut microbiota is a diverse community of microbes that maintain the stability of the intestinal environment. Dysbiosis of the gut microbiota has been linked to gastrointestinal diseases, such as colorectal cancer (CRC) - a leading cause of death for cancer patients. SUMMARY: Candidate pathogens have been identified using bacterial culture and high-throughput sequencing techniques. Currently, there is evidence to show that specific intestinal microbes drive CRC development and progression, yet their pathogenic mechanisms are still unclear. Key Messages: In this review, we describe the known healthy gut microbiota and its changes in CRC. We especially focus on exploring the pathogenic mechanisms of gut microbiota dysbiosis in CRC. This is crucial for explaining how gut microbiota dysbiosis drives the process of colorectal carcinogenesis and tumor progression. Evaluation of changes in the gut microbiota during CRC development and progression offers a new strategy for the diagnosis and treatment of this disease.
BACKGROUND: The gut microbiota is a diverse community of microbes that maintain the stability of the intestinal environment. Dysbiosis of the gut microbiota has been linked to gastrointestinal diseases, such as colorectal cancer (CRC) - a leading cause of death for cancerpatients. SUMMARY: Candidate pathogens have been identified using bacterial culture and high-throughput sequencing techniques. Currently, there is evidence to show that specific intestinal microbes drive CRC development and progression, yet their pathogenic mechanisms are still unclear. Key Messages: In this review, we describe the known healthy gut microbiota and its changes in CRC. We especially focus on exploring the pathogenic mechanisms of gut microbiota dysbiosis in CRC. This is crucial for explaining how gut microbiota dysbiosis drives the process of colorectal carcinogenesis and tumor progression. Evaluation of changes in the gut microbiota during CRC development and progression offers a new strategy for the diagnosis and treatment of this disease.
Authors: Amr Mohamed; Sylvia L Asa; Thomas McCormick; Hilmi Al-Shakhshir; Arvind Dasari; Retuerto Mauricio; Iman Salem; Lee M Ocuin; David Bajor; Richard T Lee; J Eva Selfridge; Arash Kardan; Zhenghong Lee; Norbert Avril; Shelby Kopp; Jordan M Winter; Jeffrey M Hardacre; John B Ammori; Mahmoud A Ghannoum Journal: Curr Issues Mol Biol Date: 2022-04-30 Impact factor: 2.976