| Literature DB >> 32930152 |
Dominik Raab1, Brigitta Diószeghy-Léránt2, Meret Wünnemann2, Christina Zumfelde2, Elena Cramer3, Alina Rühlemann4, Johanna Wagener4,5, Silke Gegenbauer6, Francisco Geu Flores1, Marcus Jäger4,5, Dörte Zietz3, Harald Hefter7, Andres Kecskemethy1, Mario Siebler2.
Abstract
BACKGROUND For future development of machine learning tools for gait impairment assessment after stroke, simple observational whole-body clinical scales are required. Current observational scales regard either only leg movement or discrete overall parameters, neglecting dysfunctions in the trunk and arms. The purpose of this study was to introduce a new multiple-cue observational scale, called the stroke mobility score (SMS). MATERIAL AND METHODS In a group of 131 patients, we developed a 1-page manual involving 6 subscores by Delphi method using the video-based SMS: trunk posture, leg movement of the most affected side, arm movement of the most affected side, walking speed, gait fluency and stability/risk of falling. Six medical raters then validated the SMS on a sample of 60 additional stroke patients. Conventional scales (NIHSS, Timed-Up-And-Go-Test, 10-Meter-Walk-Test, Berg Balance Scale, FIM-Item L, Barthel Index) were also applied. RESULTS (1) High consistency and excellent inter-rater reliability of the SMS were verified (Cronbach's alpha >0.9). (2) The SMS subscores are non-redundant and reveal much more nuanced whole-body dysfunction details than conventional scores, although evident correlations as e.g. between 10-Meter-Walk-Test and subscore "gait speed" are verified. (3) The analysis of cross-correlations between SMS subscores unveils new functional interrelationships for stroke profiling. CONCLUSIONS The SMS proves to be an easy-to-use, tele-applicable, robust, consistent, reliable, and nuanced functional scale of gait impairments after stroke. Due to its sensitivity to whole-body motion criteria, it is ideally suited for machine learning algorithms and for development of new therapy strategies based on instrumented gait analysis.Entities:
Mesh:
Year: 2020 PMID: 32930152 PMCID: PMC7518021 DOI: 10.12659/MSM.923147
Source DB: PubMed Journal: Med Sci Monit ISSN: 1234-1010
SMS manual.
| Trunk posture | ||
|---|---|---|
| Patient Name or ID | No pathological findings | 0 |
| Mild trunk bending (lateral or frontal) AND/OR mild vertical trunk rotation | 1 | |
| EITHER significant trunk bending (lateral or frontal) OR significant vertical trunk rotation | 2 | |
| BOTH significant trunk bending (lateral or frontal) AND significant vertical trunk rotation | 3 | |
| RaterManual
To be rated are patients dressed in underwear, who walk unsupported on a straight, marked walkway with a regular levelled surface. The walkway should be at least 10 meters in length and one meter in width. The observed motion sequence consists of start-walk-stop and a 180° turn at the end of the walkway. If a patient is using a walking aid or a mechanical device for gait (e.g., cane, orthosis, shoes) the gait has to be rated as it is. It should not be rated as the assumed gait without the walking aid or without the mechanical device. Patients using a walking frame are excluded from the SMS. Version: 1/2019 | ||
| No pathological findings | 0 | |
| Mild leg movement abnormality (slightly impaired motions at hip, knee and/or foot) | 1 | |
| Significant leg movement abnormality (strongly impaired motions at hip, knee, and/or foot) AND/OR mild knee hyperextension (genu recurvatum) | 2 | |
| Leg nearly rigid (flexed or extended) AND/OR significantly affected leg with knee hyperextension (genu recurvatum) | 3 | |
| No pathological findings | 0 | |
| Mild arm movement abnormality (slightly impaired motions at shoulder, elbow and/or hand) | 1 | |
| Significant arm movement abnormality (strongly impaired motions at shoulder, elbow and/or hand) | 2 | |
| Rigidity of the entire arm OR no active arm movement (plegia) | 3 | |
| No pathological findings | 0 | |
| Mild walking speed abnormality (walking speed is slightly reduced compared to healthy subjects) | 1 | |
| Significant walking speed abnormality (walking is seemingly achieved only with full concentration) | 2 | |
| Extremely slow and exhausting walking (end of the 10-meter walkway is reached only with great effort) | 3 | |
| No pathological findings | 0 | |
| Mild asymmetric gait (left and right steps are slightly unequal) | 1 | |
| Significant asymmetric gait (left and right steps appear to be disconnected movements) | 2 | |
| Severe asymmetric gait (body motion for left and right steps is controlled individually and interrupted by breaks, leading to a “staccato” motion) | 3 | |
| No pathological findings | 0 | |
| Mild postural instabilities, but no visible risk of falling | 1 | |
| Significant risk of falling due to stumbling AND/OR tumbling at turning | 2 | |
| The patient is using a cane | 3 | |
| Sum of the 6 subscores |
Demographical data of rated patients during score development and score validation.
| Parameter | Score development | Score validation |
|---|---|---|
| Sample size | 131 | 60 |
| Age [years]: | ||
| mean, median (SD) | 53.1, 54.0 (12.6) | 56.9, 57.8 (10.0) |
| min–max | 20–80 | 31–80 |
| Gender: | ||
| Male/Female | 100/31 | 50/10 |
| Months since stroke: | ||
| 0 to 1 | 42 | 29 |
| 1 to 2 | 24 | 23 |
| 2 to 3 | 15 | 8 |
| >3 | 46 | 0 |
| – (no stroke) | 4 | 0 |
| Affected hemisphere: | ||
| Left | 51 | 26 |
| Right | 51 | 25 |
| Brainstem | 17 | 9 |
| Inconclusive | 8 | 0 |
| None (no stroke) | 4 | 0 |
Corrected item-total correlation and Cronbach’s alpha for SMS subscores and total score for 6 sample medical raters.
| SMS item | Corrected item-total correlation | Cronbach’s alpha coefficient | |||||
|---|---|---|---|---|---|---|---|
| Rater 1 | Rater 2 | Rater 3 | Rater 4 | Rater 5 | Rater 6 | ||
| Total score | .951 | .943 | .962 | .938 | .961 | .948 | .983 |
| Trunk posture | .750 | .787 | .806 | .706 | .834 | .767 | .919 |
| Leg movement | .797 | .930 | .898 | .889 | .890 | .873 | .962 |
| Arm movement | .702 | .831 | .872 | .802 | .849 | .861 | .931 |
| Gait speed | .888 | .893 | .878 | .737 | .883 | .830 | .949 |
| Gait fluency | .815 | .848 | .801 | .772 | .839 | .847 | .939 |
| Stability/risk of falling | .900 | .903 | .920 | .911 | .922 | .932 | .974 |
Inter-rater reliability ICC2.1 of SMS subscores and SMS total score for 6 sample medical raters.
| SMS item | ICC2.1 | Reliability |
|---|---|---|
| Total score | .894 | Excellent |
| Trunk posture | .601 | Good |
| Leg movement | .796 | Excellent |
| Arm movement | .688 | Good |
| Gait speed | .726 | Good |
| Gait fluency | .714 | Good |
| Stability/risk of falling | .842 | Excellent |
Mean Spearman’s cross-correlations between SMS subscores over 6 sample medical raters.
| SMS subscore | Trunk posture | Leg movement | Arm movement | Gait speed | Gait fluency | Stability/ risk of falling |
|---|---|---|---|---|---|---|
| Trunk posture | – | .588 | .529 | .562 | .568 | .496 |
| Leg movement | .588 | – | .686 | .726 | .759 | .715 |
| Arm movement | .529 | .686 | – | .608 | .625 | .606 |
| Gait speed | .562 | .726 | .608 | – | .765 | .700 |
| Gait fluency | .568 | .759 | .625 | .765 | – | .719 |
| Stability/risk of falling | .496 | .715 | .606 | .700 | .719 | – |
All correlations are significant at the 0.01 level (2-tailed).
Spearman’s cross-correlation between the average SMS subscores and average SMS total score and established scores in stroke rehabilitation.
| SMS subscore | Ten-Meter-Walk-Test | Timed-Up-And-Go-Test | National Institutes of Health Stroke Scale | Berg Balance Scale | FIM – Item L | Barthel Index |
|---|---|---|---|---|---|---|
| Gait speed | .63 | .60 | .53 | .45 | .48 | .45 |
| Gait fluency | .63 | .56 | .51 | .46 | .46 | .44 |
| Stability/risk of falling | .54 | .50 | .52 | .44 | .44 | .39 |
| Total score | .59 | .52 | .53 | .46 | .43 | .42 |
| Trunk posture | .51 | .46 | .48 | .40 | .41 | .40 |
| Leg movement | .56 | .47 | .41 | .44 | .40 | .43 |
| Arm movement | .42 | .33 | .41 | .33 | .28 | .37 |
Negative correlation.
All correlations are significant at the 0.01 level (2-tailed).
| 0.8 | ≤ |rho| ≤ | 1 | High |
| 0.6 | ≤ |rho| < | 0.8 | Good |
| 0.4 | ≤ |rho| < | 0.6 | Moderate |
| 0.2 | ≤ |rho| < | 0.4 | Weak |
| |rho| < | 0.2 | Poor |
| 0.8 | ≤ |rho| ≤ | 1 | High |
| 0.6 | ≤ |rho| < | 0.8 | Good |
| 0.4 | ≤ |rho| < | 0.6 | Moderate |
| 0.2 | ≤ |rho| < | 0.4 | Weak |
| |rho| < | 0.2 | Poor |