Fatma Alibaz-Oner1, Rabia Ergelen2, Ilkay Ergenc3, Gizem Seven4, Ayten Yazıcı5, Ayse Cefle5, Cemal Bes6, Ozlen Atug3, Haner Direskeneli4. 1. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Fevzi Çakmak Mahallesi, Ust-Kaynarca, Pendik, Istanbul, Turkey. falibaz@gmail.com. 2. Department of Radiology, School of Medicine, Marmara University, Fevzi Çakmak Mahallesi, Ust-Kaynarca, Pendik, Istanbul, Turkey. 3. Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Marmara University, Fevzi Çakmak Mahallesi, Ust-Kaynarca, Pendik, Istanbul, Turkey. 4. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Fevzi Çakmak Mahallesi, Ust-Kaynarca, Pendik, Istanbul, Turkey. 5. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kocaeli University, Kocaeli, Turkey. 6. Division of Rheumatology, Health Science University, Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Abstract
BACKGROUNDS: Behçet's disease (BD) and Crohn's disease (CD) cannot be easily differentiated in young adults presenting with nonspecific gastrointestinal (GI) manifestations due to similar extraintestinal manifestations. We recently showed that increased common femoral vein (CFV) thickness is a distinctive feature of BD, rarely present in other inflammatory or vascular diseases with a specificity higher than 80% for the cutoff value of ≥ 0.5 mm. We suggest that CFV thickness measurement with ultrasonography (US) can be a diagnostic tool for BD. AIMS: To assess the diagnostic performance of CFV thickness measurement in the differential diagnosis of BD and CD. METHODS: Patients with BD (n = 69), CD (n = 38), and healthy controls (HC) (n = 38) were included in the study. Bilateral CFV thickness was measured with Doppler US. RESULTS: Both right and left CFV thicknesses were significantly higher in BD compared to HC and CD (for right: 0.76 mm vs 0.33 mm, for left: 0.78 mm vs 0.35 mm, p < 0.001 for both). CFV thicknesses in CD were similar to HC (p > 0.05 for both). CFV thickness was also similar between BD patients with and without GI involvement (p = 0.367). The diagnostic cutoff values of ≥ 0.5 mm for CFV thickness performed well against to both CD and HCs for discrimination of BD. The sensitivity and specificity rates were > 85% for both HC and CD. Positive and negative predictive values in our tertiary clinical setting were > 90%. CONCLUSION: We found significantly lower CFV thickness in CD compared to BD. Our results suggest that CFV wall thickness measurement is a distinctive diagnostic tool for the differentiation of BD and CD and can be helpful in daily practice for the differentiation of two diseases.
BACKGROUNDS: Behçet's disease (BD) and Crohn's disease (CD) cannot be easily differentiated in young adults presenting with nonspecific gastrointestinal (GI) manifestations due to similar extraintestinal manifestations. We recently showed that increased common femoral vein (CFV) thickness is a distinctive feature of BD, rarely present in other inflammatory or vascular diseases with a specificity higher than 80% for the cutoff value of ≥ 0.5 mm. We suggest that CFV thickness measurement with ultrasonography (US) can be a diagnostic tool for BD. AIMS: To assess the diagnostic performance of CFV thickness measurement in the differential diagnosis of BD and CD. METHODS:Patients with BD (n = 69), CD (n = 38), and healthy controls (HC) (n = 38) were included in the study. Bilateral CFV thickness was measured with Doppler US. RESULTS: Both right and left CFV thicknesses were significantly higher in BD compared to HC and CD (for right: 0.76 mm vs 0.33 mm, for left: 0.78 mm vs 0.35 mm, p < 0.001 for both). CFV thicknesses in CD were similar to HC (p > 0.05 for both). CFV thickness was also similar between BD patients with and without GI involvement (p = 0.367). The diagnostic cutoff values of ≥ 0.5 mm for CFV thickness performed well against to both CD and HCs for discrimination of BD. The sensitivity and specificity rates were > 85% for both HC and CD. Positive and negative predictive values in our tertiary clinical setting were > 90%. CONCLUSION: We found significantly lower CFV thickness in CD compared to BD. Our results suggest that CFV wall thickness measurement is a distinctive diagnostic tool for the differentiation of BD and CD and can be helpful in daily practice for the differentiation of two diseases.
Authors: I Fresko; S Ugurlu; F Ozbakir; A Celik; S Yurdakul; V Hamuryudan; H Yazici Journal: Clin Exp Rheumatol Date: 2005 Jul-Aug Impact factor: 4.473
Authors: I Hatemi; G Hatemi; A F Celik; M Melikoglu; N Arzuhal; C Mat; Y Ozyazgan; H Yazici Journal: Clin Exp Rheumatol Date: 2008 Jul-Aug Impact factor: 4.473