Literature DB >> 3292181

In-vitro activity of antifungal agents in combination with four quinolones.

M A Petrou1, T R Rogers.   

Abstract

The antifungal activity of amphotericin B (AMB), mepartricin (MEPA), 5-fluorocytosine (5FC) and three imidazoles was tested in combination with each of four quinolones against 60 clinical yeast isolates. The inhibitory activity of AMB and MEPA was marginally enhanced by the azaquinolones, nalidixic acid (NAL) and enoxacin (ENO), but there was antagonism when combined with the fluorinated quinolones ciprofloxacin (CIP) and norfloxacin (NOR). All quinolones except NAL partially antagonised 5FC. Miconazole (MCZ), ketoconazole (KTZ) and itraconazole (ITZ) were each found to be synergistic with low concentrations of the quinolones, and also with high concentrations of NAL and ENO, but were strongly antagonised by high concentrations of CIP and NOR.

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Year:  1988        PMID： 3292181

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN： 0378-6501


  11 in total

Review 1.  Combination antifungal therapy.

Authors:  Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191

Review 2.  Caenorhabditis elegans-based model systems for antifungal drug discovery.

Authors:  Cleo G Anastassopoulou; Beth Burgwyn Fuchs; Eleftherios Mylonakis
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

3.  Fungal keratitis responsive to moxifloxacin monotherapy.

Authors:  Alice Y Matoba
Journal:  Cornea       Date:  2012-10       Impact factor: 2.651

4.  Isobolographic analysis of pharmacodynamic interactions between antifungal agents and ciprofloxacin against Candida albicans and Aspergillus fumigatus.

Authors:  Theodouli Stergiopoulou; Joseph Meletiadis; Tin Sein; Paraskevi Papaioannidou; Ioannis Tsiouris; Emmanuel Roilides; Thomas J Walsh
Journal:  Antimicrob Agents Chemother       Date:  2008-02-25       Impact factor: 5.191

5.  Comparative pharmacodynamic interaction analysis between ciprofloxacin, moxifloxacin and levofloxacin and antifungal agents against Candida albicans and Aspergillus fumigatus.

Authors:  Theodouli Stergiopoulou; Joseph Meletiadis; Tin Sein; Paraskevi Papaioannidou; Ioannis Tsiouris; Emmanuel Roilides; Thomas J Walsh
Journal:  J Antimicrob Chemother       Date:  2008-12-24       Impact factor: 5.790

Review 6.  Fluoroquinolone antimicrobial agents.

Authors:  J S Wolfson; D C Hooper
Journal:  Clin Microbiol Rev       Date:  1989-10       Impact factor: 26.132

7.  In vitro and in vivo antifungal activities of DU-6859a, a fluoroquinolone, in combination with amphotericin B and fluconazole against pathogenic fungi.

Authors:  R Nakajima; A Kitamura; K Someya; M Tanaka; K Sato
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191

8.  Antifungal chemical compounds identified using a C. elegans pathogenicity assay.

Authors:  Julia Breger; Beth Burgwyn Fuchs; George Aperis; Terence I Moy; Frederick M Ausubel; Eleftherios Mylonakis
Journal:  PLoS Pathog       Date:  2007-02       Impact factor: 6.823

9.  Oral Candida in Patients with Fixed Orthodontic Appliance: In Vitro Combination Therapy.

Authors:  Wisam Alhamadi; Rafal J Al-Saigh; Nebras N Al-Dabagh; Hussam W Al-Humadi
Journal:  Biomed Res Int       Date:  2017-06-08       Impact factor: 3.411

10.  Unveiling the Synergistic Interaction Between Liposomal Amphotericin B and Colistin.

Authors:  Rita Teixeira-Santos; Elisabete Ricardo; Ricardo J Branco; Maria M Azevedo; Acácio G Rodrigues; Cidália Pina-Vaz
Journal:  Front Microbiol       Date:  2016-09-13       Impact factor: 5.640
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